Is pulsed dosing the answer to treatment of Clostridium difficile infection?

Affiliations

Comment

Dale N Gerding. Lancet Infect Dis. 2018 Mar.

. 2018 Mar;18(3):231-233.

doi: 10.1016/S1473-3099(17)30750-8. Epub 2017 Dec 19.

¹ Edward Hines Jr Veterans Affairs Hospital, Hines, IL 60141, USA. Electronic address: dale.gerding2@va.gov.

No abstract available

Comment on

Extended-pulsed fidaxomicin versus vancomycin for Clostridium difficile infection in patients 60 years and older (EXTEND): a randomised, controlled, open-label, phase 3b/4 trial.
Guery B, Menichetti F, Anttila VJ, Adomakoh N, Aguado JM, Bisnauthsing K, Georgopali A, Goldenberg SD, Karas A, Kazeem G, Longshaw C, Palacios-Fabrega JA, Cornely OA, Vehreschild MJGT; EXTEND Clinical Study Group. Guery B, et al. Lancet Infect Dis. 2018 Mar;18(3):296-307. doi: 10.1016/S1473-3099(17)30751-X. Epub 2017 Dec 19. Lancet Infect Dis. 2018. PMID: 29273269 Clinical Trial.