Is H3K4me1 at enhancers correlative or causative?

Alvaro Rada-Iglesias^{1

2}

Affiliations

¹ Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. aradaigl@uni-koeln.de.
² Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases, Cologne, Germany. aradaigl@uni-koeln.de.

Comment

Alvaro Rada-Iglesias. Nat Genet. 2018 Jan.

. 2018 Jan;50(1):4-5.

doi: 10.1038/s41588-017-0018-3.

Alvaro Rada-Iglesias^{1

2}

¹ Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. aradaigl@uni-koeln.de.
² Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases, Cologne, Germany. aradaigl@uni-koeln.de.

No abstract available

Comment on

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.
Dorighi KM, Swigut T, Henriques T, Bhanu NV, Scruggs BS, Nady N, Still CD 2nd, Garcia BA, Adelman K, Wysocka J. Dorighi KM, et al. Mol Cell. 2017 May 18;66(4):568-576.e4. doi: 10.1016/j.molcel.2017.04.018. Epub 2017 May 5. Mol Cell. 2017. PMID: 28483418 Free PMC article.
Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.
Rickels R, Herz HM, Sze CC, Cao K, Morgan MA, Collings CK, Gause M, Takahashi YH, Wang L, Rendleman EJ, Marshall SA, Krueger A, Bartom ET, Piunti A, Smith ER, Abshiru NA, Kelleher NL, Dorsett D, Shilatifard A. Rickels R, et al. Nat Genet. 2017 Nov;49(11):1647-1653. doi: 10.1038/ng.3965. Epub 2017 Oct 2. Nat Genet. 2017. PMID: 28967912 Free PMC article.
Identification of H3K4me1-associated proteins at mammalian enhancers.
Local A, Huang H, Albuquerque CP, Singh N, Lee AY, Wang W, Wang C, Hsia JE, Shiau AK, Ge K, Corbett KD, Wang D, Zhou H, Ren B. Local A, et al. Nat Genet. 2018 Jan;50(1):73-82. doi: 10.1038/s41588-017-0015-6. Epub 2017 Dec 18. Nat Genet. 2018. PMID: 29255264 Free PMC article.

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