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. 2018 Mar:133:38-44.
doi: 10.1016/j.apradiso.2017.12.011. Epub 2017 Dec 13.

Radiosynthesis and modified quality control of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) for brain tumor imaging

Ibrahim Saber Siddiq  1 , Shoukar Tawfik Atwa  2 , Sayed Ahmed Shama  2 , Magdy Hafez Eltaoudy  3 , Walid Mohamed Omar  4
Affiliations

Radiosynthesis and modified quality control of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) for brain tumor imaging

Ibrahim Saber Siddiq et al. Appl Radiat Isot. 2018 Mar.

Abstract

O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) is the most promising radio-labeled amino acid tracer for brain tumor imaging due to the limitation of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and L-methyl-[11C]methionine (11C-MET). However, it has some limitations in radiosynthesis and related quality control that make it less frequently used in many PET centers, in this study, we report a new modification of [18F]FET production using a commercially available fully automated GRP SCINTOMICS module overcoming some of the existing limitations along with a suggestion of a simplified quality control procedure with special focus placed on enantiomeric and radiochemical purity. ([18F]FET) was produced in high radiochemical and enantiomeric purity more than 99% and non-decay corrected yield 25±5% in about 55min.

Keywords: (18)FET; Amino acid; Brain tumor; Quality control; Radiosynthesis; TLC.

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