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. 2018 Jan-Feb;32(1):121-124.
doi: 10.21873/invivo.11213.

Early PET-CT After Stereotactic Radiotherapy for Stage 1 Non-small Cell Lung Carcinoma Is Predictive of Local Control

Marguerite Tyran  1 , Nathalie Charrier  2 , Julien Darreon  1 , Anne Madroszyk  3 , Agnes Tallet  1 , Naji Salem  4
Affiliations

Early PET-CT After Stereotactic Radiotherapy for Stage 1 Non-small Cell Lung Carcinoma Is Predictive of Local Control

Marguerite Tyran et al. In Vivo. 2018 Jan-Feb.

Abstract

Background/aim: Radiological evaluation after stereotactic-body-radiotherapy (SBRT) for non-small-cell lung carcinoma (NSCLC) is often difficult due to lung radiation-induced image modifications on computed tomographic (CT) scan. The aim of this study was to evaluate positron-emission tomography-computed tomography (PET-CT) using fluorodeoxyglucose after SBRT in primary lung cancer.

Patients and methods: Eighteen patients with histologically proven NSCLC were treated with SBRT. All had PET-CT evaluations before treatment, at 2 to 3 months and at 1 year post SBRT during the follow-up.

Results: Early PET-CT in 12/18 patients who did not experience local failure did not show any progression. No conclusion could be drawn in four cases because early PET-CT was disturbed by inflammatory reaction. Early PET-CT was not predictive of late outcome for two patients, as it showed a significant response followed by disease progression on late evaluation.

Conclusion: Early PET response appears to correlate with local control at 1 year post SBRT.

Keywords: Lung cancer; PET-computed tomographic; SBRT; local control.

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