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. 2017 Dec;5(4):167-174.
doi: 10.1007/s40142-017-0131-8. Epub 2017 Oct 11.

Primary Open-Angle Glaucoma Genetics in African Americans

Nicole A Restrepo  1 , Jessica N Cooke Bailey  1
Affiliations

Primary Open-Angle Glaucoma Genetics in African Americans

Nicole A Restrepo et al. Curr Genet Med Rep. 2017 Dec.

Abstract

Purpose of review: Individuals of African descent are at highest risk for developing primary open-angle glaucoma (POAG), a devastating disease and major contributor of blindness worldwide. Currently, there is a large dearth of knowledge in this area despite a critical need for better understanding the underlying genetic and environmental factors afflicting this population. Here we highlight the current literature exploring the genetics of POAG in African Americans.

Recent findings: Current studies have yet to replicate European POAG index variants (i.e. CDKN2B-AS1 and SIX1/SIX6) in African Americans or to definitely exclude that these loci contribute to risk in African descent populations. Recent studies have evaluated clinical features that may account for some differences in POAG risk between African Americans and European Americans.

Summary: In summary, little headway has been made in elucidating the genetics of primary open-angle glaucoma in African Americans and other individuals of African descent.

Keywords: African American primary open angle glaucoma; glaucoma genetics.

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References

    1. Kwon YH, Fingert JH, Kuehn MH, Alward WL. Primary open-angle glaucoma. N Engl J Med. 2009 Mar 12;360(11):1113–24. - PMC - PubMed
    1. Friedman DS, Wolfs RC, O’Colmain BJ, Klein BE, Taylor HR, West S, Leske MC, Mitchell P, Congdon N, Kempen J. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004 Apr;122(4):532–8. - PMC - PubMed
    1. Doucette LP, Rasnitsyn A, Seifi M, Walter MA. The interactions of genes, age, and environment in glaucoma pathogenesis. Surv Ophthalmol. 2015 Jul;60(4):310–26. - PubMed
    1. Wiggs JL. Glaucoma Genes and Mechanisms. Prog Mol Biol Transl Sci. 2015;134:315–42. - PMC - PubMed
    1. Morgan-Davies J, Taylor N, Hill AR, Aspinall P, O’Brien CJ, Azuara-Blanco A. Three dimensional analysis of the lamina cribrosa in glaucoma. Br J Ophthalmol. 2004 Oct;88(10):1299–304. - PMC - PubMed

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