The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review

Nele Boeckx¹, Katleen Janssens², Guy Van Camp³, Marika Rasschaert⁴, Konstantinos Papadimitriou⁵, Marc Peeters⁶, Ken Op de Beeck⁷

Affiliations

¹ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address: Nele.Boeckx@uantwerpen.be.
² Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. Electronic address: Katleen.Janssens@student.uantwerpen.be.
³ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address: Guy.Vancamp@uantwerpen.be.
⁴ Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: Marika.Rasschaert@uza.be.
⁵ Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: Konstantinos.Papadimitriou@uza.be.
⁶ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: Marc.Peeters@uza.be.
⁷ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address: Ken.Opdebeeck@uantwerpen.be.

PMID: 29279095
DOI: 10.1016/j.critrevonc.2017.11.003

The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review

Nele Boeckx et al. Crit Rev Oncol Hematol. 2018 Jan.

. 2018 Jan:121:1-10.

doi: 10.1016/j.critrevonc.2017.11.003. Epub 2017 Nov 7.

Authors

Nele Boeckx¹, Katleen Janssens², Guy Van Camp³, Marika Rasschaert⁴, Konstantinos Papadimitriou⁵, Marc Peeters⁶, Ken Op de Beeck⁷

Affiliations

¹ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address: Nele.Boeckx@uantwerpen.be.
² Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium. Electronic address: Katleen.Janssens@student.uantwerpen.be.
³ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address: Guy.Vancamp@uantwerpen.be.
⁴ Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: Marika.Rasschaert@uza.be.
⁵ Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: Konstantinos.Papadimitriou@uza.be.
⁶ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Department of Oncology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Edegem, Belgium. Electronic address: Marc.Peeters@uza.be.
⁷ Center of Oncological Research (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Center of Medical Genetics, University of Antwerp and Antwerp University Hospital, Prins Boudewijnlaan 43/6, 2650 Edegem, Belgium. Electronic address: Ken.Opdebeeck@uantwerpen.be.

PMID: 29279095
DOI: 10.1016/j.critrevonc.2017.11.003

Abstract

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. It has been reported that left- and right-sided CRC harbor varying disease characteristics, which leads to a difference in prognosis and response to therapy. Recently, there have been retrospective studies about tumor location in metastatic CRC (mCRC) and its potential to predict the effect of anti-vascular endothelial growth factor and anti-epidermal growth factor receptor (anti-EGFR) therapies. In this review, we provide a comprehensive overview of the latest trials studying the predictive value of primary tumor location in mCRC and discuss biomarkers that might be associated with the differences in treatment response. Although data need to be interpreted with caution due to the absence of randomized trials stratified based on tumor location, patients with left-sided CRC seem to benefit more from anti-EGFR therapy than patients with right-sided CRC. Further clinical trials, stratified for tumor location, are warranted.

Keywords: Anti-EGFR therapy; Anti-VEGF therapy; Biomarkers; Predictive value; Primary tumor location.

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The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review

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The predictive value of primary tumor location in patients with metastatic colorectal cancer: A systematic review

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