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. 2017 Oct-Dec;11(4):417-421.
doi: 10.4103/ejd.ejd_191_17.

Evaluation of intracanal acetazolamide in late reimplanted rat teeth

Camila Paiva Perin  1 , Vula Papalexiou  1 , Aline Cristina Batista Rodrigues Johann  1 , Natanael Henrique Ribeiro Mattos  1 , Fernando Henrique Westphalen  1 , Vânia Portela Ditzel Westphalen  1
Affiliations

Evaluation of intracanal acetazolamide in late reimplanted rat teeth

Camila Paiva Perin et al. Eur J Dent. 2017 Oct-Dec.

Abstract

Objective: The aim of this study was to evaluate the use of acetazolamide combined with different agents as intracanal medication in late reimplanted rat teeth.

Materials and methods: In 100 Wistar rats, divided into 5 groups of 20, one of the following medications was used: Acetazolamide liquid (AL); AL with calcium hydroxide powder (ALHC); acetazolamide powder with AL; acetazolamide powder with physiological solution; and calcium hydroxide with physiological solution (control). At 30 and 60 days after reimplantation, the animals were sacrificed, tissues were processed, and cuts were stained with hematoxylin and eosin. An optical microscope was used to determine the following: percentage of inflammatory root resorption (RRI); percentage of substitute root resorption (RRS); and presence of ankylosis. The data obtained was submitted for statistical analysis.

Results: Group ALHC had a significantly higher RRS than the control group at 60 days (P = 0.01). Group AL showed significantly less ankylosis than the other groups, including the control, at 30 days. AL showed results similar to those of the control group with respect to RRS.

Conclusion: Acetazolamide has the potential to be an effective intracanal medication.

Keywords: Acetazolamide; calcium hydroxide; intracanal medication; resorption.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
a / b.Images of histological sections, the AL group at 30 and 60 days. Reduced presence of ankylosis 30 days and moderate presence of RRS gaps. Increase 100X, c / d.Imagens of histological sections, the ALHC group at 30 and 60 days. Moderate presence and ankylosis and high presence of RRS gaps. Increase 100X, e / f.Imagens of histological sections, the APAL group at 30 and 60 days. Moderate presence of ankylosis and moderate presence of RRS gaps. Increase 100X, g / h. Images of histological sections, the APSF group at 30 and 60 days. Moderate presence of ankylosis and moderate presence of RRS gaps. Increase 100X, i / j. Images of histological sections, the control group at 30 and 60 days. Moderate presence of ankylosis and moderate presence of RRI gaps. Increase 100X
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References

    1. Tronstad L. Root resorption – Etiology, terminology and clinical manifestations. Endod Dent Traumatol. 1988;4:241–52. - PubMed
    1. Andreasen JO, Borum MK, Jacobsen HL, Andreasen FM. Replantation of 400 avulsed permanent incisors 4. Factors related to periodontal ligament healing. Endod Dent Traumatol. 1995;11:76–89. - PubMed
    1. Babaji P, Melkundi M, Devanna R, Suresh BS, Chaurasia VR, Gopinath PV, et al. In vitro comparative evaluation of different storage media (hank's balanced salt solution, propolis, Aloe vera, and pomegranate juice) for preservation of avulsed tooth. Eur J Dent. 2017;11:71–5. - PMC - PubMed
    1. Andreasen JO, Andreasen FM, Andersson L. Textbook and Color Atlas of Traumatic Injuries to the Teeth. Oxford, UK ; Ames, Iowa: Blackwell Munksgaard; 2007.
    1. Mori GG, Garcia RB. Microscopic study of the effect of root surface treatment with acetazolamida in avulsed and reimplanted rat teeth. Rev Fac Odontol Bauru. 2002;10:180–5.