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Review
. 2018 Mar;34(3):409-415.
doi: 10.1007/s00381-017-3705-6. Epub 2017 Dec 26.

Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition

Matheus Fernando Manzolli Ballestero  1 , Dinark Conceição Viana  2 , Thiago Lyrio Teixeira  2 , Marcelo Volpon Santos  2 , Ricardo Santos de Oliveira  2
Affiliations
Review

Hypertrophic olivary degeneration in children after posterior fossa surgery. An underdiagnosed condition

Matheus Fernando Manzolli Ballestero et al. Childs Nerv Syst. 2018 Mar.

Abstract

Background: Hypertrophic olivary degeneration (HOD) is a rare transsynaptic form of degeneration occurring after injury to the dentato-rubro-olivary pathway ("Guillain-Mollaret triangle"). The majority of studies have described HOD resulting from posterior fossa (PF) hemorrhage or infarction. HOD in patients undergoing PF surgery has not been well characterized. These lesions are rare and symptomatic children with HOD are even more uncommon. The purpose of this study was to evaluate HOD that develops after PF operations in children.

Materials and methods: A literature review was carried out describing 37 pediatric cases of HOD in 13 articles. In addition, two new cases of our own experience were included.

Conclusions: HOD is a rare complication related after PF tumors surgery and symptoms may be misdiagnosed with pediatric cerebellar mutism syndrome. Children with HOD usually do not develop palatal tremor but ataxia is common.

Keywords: Hypertrophic olivary degeneration; Neuroncology; Pediatric neurosurgery; Posterior fossa syndrome.

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