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Review
. 2016 Nov;22(11):1025-1029.

[Autophagy and phenotypic modulation of corpus cavernosum smooth muscle cells in hypoxia-induced erectile dysfunction]

[Article in Chinese]
Ji-Kun Deng  1 , Yan Tan  1
Affiliations
  • PMID: 29281213
Review

[Autophagy and phenotypic modulation of corpus cavernosum smooth muscle cells in hypoxia-induced erectile dysfunction]

[Article in Chinese]
Ji-Kun Deng et al. Zhonghua Nan Ke Xue. 2016 Nov.

Abstract
in English, Chinese

The correlation between hypoxia and erectile dysfunction (ED) has been universally acknowledged for decades in the academic world. The phenotypic modulation of corpus cavernosum smooth muscle cells (CCSMCs) is regarded as one of the factors of hypoxia-induced ED, but the underlying mechanisms remain unclear. Recent researches show some correlation between autophagy and phenotypic modulation of CCSMCs, which may be associated with the overexpressions of PDGF, TGF-β, and vasoactive factors in the organism following hypoxia.

缺氧与勃起功能障碍（ED）的相关性在学术界已被公认数十年之久，阴茎海绵体平滑肌细胞（CCSMC）表型的转换目前被认为是缺氧并发ED的机制之一，但关于表型转化更深一步机制尚不明确。最近的研究发现，细胞自噬与平滑肌的表型转化有着一定的相关性，而缺氧后机体内血小板源性生长因子(PDGF)、转化生长因子β(TGF-β)、 血管活性因子等物质的过表达可能是两者之间的联系点。.

Keywords: autophagy; corpus cavernosum smooth muscle cell; hypoxia; phenotypic modulation.

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