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. 2017 Dec 27;12(12):e0190225.
doi: 10.1371/journal.pone.0190225. eCollection 2017.

Vertebral cross-sectional growth: A predictor of vertebral wedging in the immature skeleton

Ervin Poorghasamians  1 , Patricia C Aggabao  1 , Tishya A L Wren  2 , Skorn Ponrartana  1 , Vicente Gilsanz  1   2   3
Affiliations

Vertebral cross-sectional growth: A predictor of vertebral wedging in the immature skeleton

Ervin Poorghasamians et al. PLoS One. .

Abstract

The degree of vertebral wedging, a key structural characteristic of spinal curvatures, has recently been found to be negatively related to vertebral cross-sectional area (CSA). The purpose of this longitudinal study was to examine the relation between vertebral cross-sectional growth and vertebral wedging progression within the immature lumbar spine. Using magnetic resonance imaging (MRI), we analyzed the potential association between increases in lumbar vertebral CSA and changes in L5 vertebral wedging in 27 healthy adolescent girls (ages 9-13 years) twice within a two-year period. Vertebral CSA growth was negatively associated with changes in posteroanterior vertebral wedging (r = -0.61; p = 0.001). Multiple regression analysis showed that this relation was independent of gains in age, height, and weight. When compared to the 14 girls whose vertebral wedging progressed, the 13 subjects whose vertebral wedging decreased had significantly greater vertebral cross-sectional growth (0.39 ± 0.25 vs. 0.75 ± 0.23 cm2; p = 0.001); in contrast, there were no significant differences in increases in age, height, or weight between the two groups. Changes in posteroanterior vertebral wedging and the degree of lumbar lordosis (LL) positively correlated (r = 0.56, p = 0.002)-an association that persisted even after adjusting for gains in age, height, and weight. We concluded that in the immature skeleton, vertebral cross-sectional growth is an important determinant of the plasticity of the vertebral body; regression of L5 vertebral wedging is associated with greater lumbar vertebral cross-sectional growth, while progression is the consequence of lesser cross-sectional growth.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Simple linear regression between changes in vertebral CSA and vertebral wedging (r = -0.611; p = 0.001).
Fig 2
Fig 2. Boxplot showing differences in vertebral cross-sectional growth between girls with increased (n = 14) and decreased vertebral body wedging (n = 13); p = 0.001.
See this image and copyright information in PMC

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