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. 2018 May;52(3):179-182.
doi: 10.4132/jptm.2017.10.09. Epub 2017 Dec 27.

Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report

Ji Hye Moon  1 , Kyoungbun Lee  1 , Han-Kwang Yang  2   3 , Woo Ho Kim  1   3
Affiliations

Duodenal Adenocarcinoma of Brunner Gland Origin: A Case Report

Ji Hye Moon et al. J Pathol Transl Med. 2018 May.

Abstract

We report a case of adenocarcinoma originating from the duodenal Brunner glands in a 47-year-old female patient. The lesion was 0.8 cm in extent and located at the posterior wall of the first part of the duodenum. Histologically, the tumor showed transition from non-neoplastic Brunner glands through dysplastic epithelium into adenocarcinoma. The carcinoma cells were strongly positive for MUC6 protein, which is an epithelial marker for the Brunner glands. Tumor protein p53 was overexpressed in the carcinoma cells, but not in the non-neoplastic or dysplastic epithelium. Dystrophic calcification was predominant. This is the first case report of duodenal adenocarcinoma of Brunner gland origin in Korea.

Keywords: Adenocarcinoma; Brunner glands; Duodenum.

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Conflict of interest statement

Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1.
Fig. 1.
Gross and microscopic images of Brunner gland adenocarcinoma. (A) Endoscopy of the duodenal carcinoma showing a 0.8-cm lesion with central depression in the posterior wall of the first segment of duodenum. (B) Gross view. (C) Microscopic image of the endoscopic biopsy showing well-differentiated adenocarcinoma consisting of branching glands. (D) High-power view demonstrates psammoma-like structures of dystrophic calcification.
Fig. 2.
Fig. 2.
Histology and immunohistochemistry of the lesion. (A) Low power view of resected duodenal segment. (B) Higher power view of adenocarcinoma. (C) MUC6 stain showed diffuse positivity in adenocarcinoma as well as adjacent Brunner glands. (D) Negative p53 staining in normal Brunner glands. (E) Focal positive p53 staining in dysplasia. (F) Strong p53 staining in adenocarcinoma.
See this image and copyright information in PMC

References

    1. Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN, Lantz PE, Isaacson PG. Gastrointestinal pathology: an atlas and text. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 471.
    1. Kamei K, Yasuda T, Nakai T, Takeyama Y. A case of adenocarcinoma of the duodenum arising from Brunner's gland. Case Rep Gastroenterol. 2013;7:433–7. - PMC - PubMed
    1. Chang HK, Yu E, Kim J, et al. Adenocarcinoma of the small intestine: a multi-institutional study of 197 surgically resected cases. Hum Pathol. 2010;41:1087–96. - PubMed
    1. Koizumi M, Sata N, Yoshizawa K, Kurihara K, Yasuda Y. Carcinoma arising from Brunner's gland in the duodenum after 17 years of observation: a case report and literature review. Case Rep Gastroenterol. 2007;1:103–9. - PMC - PubMed
    1. Ohta Y, Saitoh K, Akai T, Uesato M, Ochiai T, Matsubara H. Early primary duodenal carcinoma arising from Brunner's glands synchronously occurring with sigmoid colon carcinoma: report of a case. Surg Today. 2008;38:756–60. - PubMed

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