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Meta-Analysis
. 2017 Dec 28;18(12):3195-3200.
doi: 10.22034/APJCP.2017.18.12.3195.

Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis

Reza Nafisi Moghadam  1 , Amir Pasha Amlelshahbaz, Nasim Namiranian, Mohammad Sobhan-Ardekani, Mahmood Emami-Meybodi, Ali Dehghan, Masoud Rahmanian, Seid Kazem Razavi-Ratki
Affiliations
Meta-Analysis

Comparative Diagnostic Performance of Ultrasonography and 99mTc-Sestamibi Scintigraphy for Parathyroid Adenoma in Primary Hyperparathyroidism; Systematic Review and Meta- Analysis

Reza Nafisi Moghadam et al. Asian Pac J Cancer Prev. .

Abstract

Objective: Ultrasonography (US) and parathyroid scintigraphy (PS) with 99mTc-MIBI are common methods for preoperative localization of parathyroid adenomas but there discrepancies exist with regard to diagnostic accuracy. The aim of the study was to compare PS and US for localization of parathyroid adenoma with a systematic review and meta-analysis of the literature. Methods: Pub Med, Scopus (EMbase), Web of Science and the reference lists of all included studies were searched up to 1st January 2016. The search strategy was according PICO characteristics. Heterogeneity between the studies was accounted by P < 0.1. Point estimates were pooled estimate of sensitivity, specificity and positive predictive value of SPECT and ultrasonography with 99% confidence intervals (CIs) by pooling available data. Data analysis was performed using Meta-DiSc software (version 1.4). Results: Among 188 studies and after deletion of duplicated studies (75), a total of 113 titles and abstracts were studied. From these, 12 studies were selected. The meta-analysis determined a pooled sensitivity for scintigraphy of 83% [99% confidence interval (CI) 96.358 -97.412] and for ultra-sonography of 80% [99% confidence interval (CI) 76-83]. Similar results for specificity were also obtained for both approache. Conclusion: According this meta- analysis, there were no significant differences between the two methods in terms of sensitivity and specificity. There were overlaps in 99% confidence intervals. Also features of the two methods are similar.

Keywords: Parathyroid neoplasms; ultrasonography; radionuclide imaging; sensitivity and specificity.

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Figures

Figure 1
Figure 1
Flow Diagram of Article Selection Process
Figure 2
Figure 2
The Quality Assessment of Included Studies According Modified QUADAS Score 2
Figure 3
Figure 3
The Forest Plot of Pooled US Sensitivity
Figure 4
Figure 4
The Forest Plot of Pooled SP Sensitivity
Figure 5
Figure 5
The Forest Plot of Pooled US SROC
Figure 6
Figure 6
The Forest Plot of Pooled PS SROC
See this image and copyright information in PMC

References

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