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Meta-Analysis
. 2017 Dec 28;18(12):3201-3206.
doi: 10.22034/APJCP.2017.18.12.3201.

Breast Cancer Risk From Modifiable and Non-Modifiable Risk Factors among Women in Southeast Asia: A Meta-Analysis

Ricvan Dana Nindrea  1 , Teguh Aryandono, Lutfan Lazuardi
Affiliations
Meta-Analysis

Breast Cancer Risk From Modifiable and Non-Modifiable Risk Factors among Women in Southeast Asia: A Meta-Analysis

Ricvan Dana Nindrea et al. Asian Pac J Cancer Prev. .

Abstract

Objective: The aim of this study was to determine breast cancer risk from modifiable and non-modifiable factors among women in Southeast Asia. Methods: This meta-analysis was performed on research articles on breast cancer risk factors in PubMed, ProQuest and EBSCO databases published between 1997 and October 2017. Pooled odds ratios (OR) are calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3). Results: From a total of 1,211 articles, 15 studies (1 cohort and 14 case control studies) met the criteria for systematic review. Meta-analysis results showed that of the known modifiable risk factors for breast cancer, parity (nulipara) had the highest odd ratio (OR = 1.85 [95% CI 1.47-2.32]) followed by body mass index (overweight) (OR = 1.61 [95% CI 1.43-1.80]) and use of oral contraceptives (OR = 1.27 [95% CI 1.07-1.51]). Of non-modifiable risk factors, family history of breast cancer had the highest odd ratio (OR = 2.53 [95% CI 1.25-5.09]), followed by age (≥ 40 years) (OR = 1.53 [95% CI 1.34-1.76]) and menopausal status (OR = 1.44 [95% CI 1.26-1.65]). Conclusion: This analysis confirmed associations between both modifiable risk factors (parity, body mass index and use of oral contraceptives) and non-modifiable risk factors (family history of breast cancer, age and menopausal status) with breast cancer.

Keywords: Breast cancer; risk factors; Southeast Asia.

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Figures

Figure 1
Figure 1
Flow Diagram Research Procedure
Figure 2
Figure 2
Forest Plots Modifiable Breast Cancer Risk Factors in the Southeast Asia
Figure 3
Figure 3
Funnel Plots Modifiable Breast Cancer Risk Factors in the Southeast Asia
Figure 4
Figure 4
Forest Plots non Modifiable Breast Cancer Risk Factors in the Southeast Asia
Figure 5
Figure 5
Funnel Plots non Modifiable Breast Cancer Risk Factors in the Southeast Asia
See this image and copyright information in PMC

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