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Comment
. 2018 Jan 17;37(2):164-166.
doi: 10.15252/embj.201798618. Epub 2017 Dec 27.

Colonic epithelium rejuvenation through YAP/TAZ

Rui Chen  1 , Kun-Liang Guan  1
Affiliations
Comment

Colonic epithelium rejuvenation through YAP/TAZ

Rui Chen et al. EMBO J. .

Abstract

Stem cells are critical for normal tissue homeostasis and injury‐induced regeneration, but how wounding affects tissue regeneration at the cellular and molecular levels is not yet fully understood. A new study by Yui et al (2018) demonstrates that the extracellular matrix (ECM) remodeling modulates intestinal stem cells in tissue repair and regeneration via activation of the Hippo pathway effectors YAP/TAZ.

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Figures

Figure 1
Figure 1. YAP/TAZ mediate extracellular signals to intestinal stem cell activation and tissue repair
Upon tissue damage, remodeling of extracellular matrix such as collagen/Wnt could activate FAK/Src and YAP/TAZ, leading to stem cell activation and tissue regeneration.
See this image and copyright information in PMC

Comment on

References

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