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. 2018 Mar;275(3):823-825.
doi: 10.1007/s00405-017-4858-3. Epub 2017 Dec 27.

Amiodarone-associated bilateral vestibulopathy

Robert Gürkov  1 , Leonardo Manzari  2 , Alexander Blödow  3 , Angela Wenzel  4 , Dusan Pavlovic  5 , Leonal Luis  6
Affiliations

Amiodarone-associated bilateral vestibulopathy

Robert Gürkov et al. Eur Arch Otorhinolaryngol. 2018 Mar.

Abstract

Background: Bilateral vestibulopathy (BVP) is a debilitating disorder characterized by the hypofunction of both vestibular end organs or nerves. The most frequent identifiable causes of BVP are ototoxic drug effects, infectious and autoimmune disorders. The majority of cases, however, remain idiopathic.

Methods: Medical records of patients diagnosed with idiopathic BVP were examined in five dizziness clinics.

Results: We identified 126 patients with "idiopathic" BVP. Out of these, 15 patients had a history of Amiodarone treatment before the diagnosis of BVP, resulting in a 12% prevalence.

Conclusion: The present report supports the hypothesis that Amiodarone can cause BVP. Vestibular examination in patients taking Amiodarone and suffering from balance-related symptoms are recommended, to recognize this adverse effect as early as possible and allow for an informed judgement on a potential dose reduction or withdrawal for recovery of the vestibular function.

Keywords: Amiodarone; Bilateral vestibulopathy; Neurotoxicity; Ototoxicity.

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References

    1. Otol Neurotol. 2011 Jul;32(5):812-7 - PubMed
    1. Arch Neurol. 2009 Jul;66(7):865-9 - PubMed
    1. Clinics (Sao Paulo). 2012;67(4):305-11 - PubMed
    1. ORL J Otorhinolaryngol Relat Spec. 2015 Sep 15;77(4):197-218 - PubMed
    1. J Am Coll Cardiol. 1997 Sep;30(3):791-8 - PubMed

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