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Comment
. 2017 Dec 28;130(26):2816-2818.
doi: 10.1182/blood-2017-10-808576.

VAMP-3 mediates platelet endocytosis

Charles J Lowenstein  1
Affiliations
Comment

VAMP-3 mediates platelet endocytosis

Charles J Lowenstein. Blood. .

Abstract

In this issue of Blood, Banerjee et al show that circulating platelets engulf thrombotic proteins and then recycle them during platelet activation and thrombosis.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Platelets take up and release fibrinogen. Platelets engulf fibrinogen from the blood and load it into endosomes through the process of endocytosis. Endosomes containing fibrinogen fuse with granules containing VWF. The protein VAMP-3 facilitates this membrane fusion. During platelet activation, platelets release fibrinogen and VWF into the blood to promote platelet aggregation and thrombosis. Professional illustration by Somersault18:24.
See this image and copyright information in PMC

Comment on

References

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