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. 2017 Dec;14(6):5997-6001.
doi: 10.3892/etm.2017.5273. Epub 2017 Oct 10.

Correlation between CD64 and PCT levels in cerebrospinal fluid and degree of hearing impairment sequelae in neonates with purulent meningitis

Cui Liu  1   2 , Dongchi Zhao  1
Affiliations

Correlation between CD64 and PCT levels in cerebrospinal fluid and degree of hearing impairment sequelae in neonates with purulent meningitis

Cui Liu et al. Exp Ther Med. 2017 Dec.

Abstract

This study investigated the possible correlation between the degree of hearing impairment caused by neonatal purulent meningitis and the levels of CD64 and PCT in cerebrospinal fluid of patients, and assessed the prognostic value of such levels. We recorded data from 156 cases of neonatal purulent meningitis retrospectively. All the patients received brainstem response audiometry, and cerebrospinal fluid samples were collected within the first day after admission through lumbar puncture. Flow cytometry was used to detect CD64 levels and enzyme-linked fluorescent assay was used to detect PCT levels. The children with hearing impairment were followed up for 1 year and brainstem response audiometry was performed again in them. We found that 43.59% of the children showed different degrees of hearing impairment, and 55% of them did not fully recover. The levels of PCT and CD64 in cerebrospinal fluid of children with hearing impairment were significantly higher than those of children with normal hearing (P<0.01). The levels of PCT and CD64 in mild, moderate and severe hearing impaired children increased gradually with higher degrees of impairment, and the differences between groups were significant (P<0.01). During the follow-up, it was found that the levels of PCT and CD64 in children correlated well with the degree of hearing recovery, and the differences between groups were significant (P<0.01). In our study, approximately 1/4 children with purulent meningitis showed long-term hearing impairment. Based on our analyses, the levels of CD64 and PCT in cerebrospinal fluid can be used to predict the degree and long-term prognosis of hearing impairment caused by purulent meningitis in children.

Keywords: CD64; PCT; cerebrospinal fluid; hearing impairment; purulent meningitis.

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Figures

Figure 1.
Figure 1.
Comparison of PCT levels between patients with normal hearing and hearing impairment by enzyme-linked fluorescence. **P<0.01 compared with normal hearing group.
Figure 2.
Figure 2.
Comparison of PCT levels among patients with different degrees of hearing impairment by enzyme-linked fluorescence tests. **P<0.01 compared with the mild hearing impairment group; ##P<0.01 compared with the moderate hearing impairment group.
Figure 3.
Figure 3.
The comparison of PCT levels between patients with different degrees of hearing recovery. Enzyme-linked fluorescence tests showed that the levels of PCT in patients with partial recovery and non-recovery were significantly higher than that in patients with complete recovery (P<0.01), and the level of PCT in patients with non-recovery was significantly higher than that in patients with partial recovery (P<0.01). **P<0.01 compared with the patients with complete recovery; ##P<0.01 compared with the patients with partial recovery.
Figure 4.
Figure 4.
Comparison of CD64 levels between patients in the normal hearing and hearing impairment groups by flow cytometry. **P<0.01 compared with normal hearing group.
Figure 5.
Figure 5.
Comparison of CD64 levels among patients with different degree of hearing impairment. **P<0.01 compared with the mild hearing impairment group; ##P<0.01 compared with the moderate hearing impairment group.
Figure 6.
Figure 6.
Comparison of PCT levels between patients with different degrees of hearing recovery. **P<0.01 compared with the patients with complete recovery; ##P<0.01 compared with the patients with partial recovery.
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