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Editorial
. 2017 Dec;5(23):469.
doi: 10.21037/atm.2017.09.03.

Nrf2: a promising trove for diabetic wound healing

Amruta Jindam  1 , Veera Ganesh Yerra  1 , Ashutosh Kumar  1
Affiliations
Editorial

Nrf2: a promising trove for diabetic wound healing

Amruta Jindam et al. Ann Transl Med. 2017 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Nrf2 activation and its effect on improved diabetic wound healing. Nrf2 is sequestered with Keap1 in the cytosol of cell. Keap1 stabilizes Nrf2 by its ubiquitination and keeps it in inactive form. When Nrf2 activators like Sulforaphane and Cinnamaldehyde are given, Nrf2 dissociates from Keap1 and enters into nucleus. There it forms heterodimer with musculoaponeurotic fibrosarcoma (Maf) protein which is able to bind DNA and regulate gene expression. This heterodimer then binds to antioxidant response element (ARE) and produces different antioxidants like HO-1 and NQO1 which are useful to lessen the cellular damage due to reactive oxygen species (ROS). Such activation of Nrf2 leads to increased levels of TGFβ-1 and reduction in MMP9, apoptosis and oxidative stress associated with impaired diabetic wound healing. Thermal gradient between the normal skin tissue and wound skin tissue is increased when wound healing is impaired in diabetes. This can also be reversed by the activation of Nrf2. Nrf2, nuclear related factor 2.
See this image and copyright information in PMC

Comment on

  • An Essential Role of NRF2 in Diabetic Wound Healing.
    Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou S, Wong PK, Wondrak GT, Zheng H, Zhang DD. Long M, et al. Diabetes. 2016 Mar;65(3):780-93. doi: 10.2337/db15-0564. Epub 2015 Dec 30. Diabetes. 2016. PMID: 26718502 Free PMC article.

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