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Editorial
. 2017 Dec;5(23):470.
doi: 10.21037/atm.2017.09.22.

Sodium-glucose cotransporter 2 inhibitors and death and heart failure in type 2 diabetes

Affiliations
Editorial

Sodium-glucose cotransporter 2 inhibitors and death and heart failure in type 2 diabetes

Hidekatsu Yanai. Ann Transl Med. 2017 Dec.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The change in estimated glomerular filtration rate (eGFR) and the possible mechanisms for improvement in heart failure due to sodium-glucose cotransporter 2 inhibitors (SGLT2i). The graph was modified from Figure 1 in (9).

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References

    1. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 2015;373:2117-28. 10.1056/NEJMoa1504720 - DOI - PubMed
    1. Monami M, Dicembrini I, Mannucci E. Effects of SGLT-2 inhibitors on mortality and cardiovascular events: a comprehensive meta-analysis of randomized controlled trials. Acta Diabetol 2017;54:19-36. 10.1007/s00592-016-0892-7 - DOI - PubMed
    1. Saad M, Mahmoud AN, Elgendy IY, et al. Cardiovascular outcomes with sodium-glucose cotransporter-2 inhibitors in patients with type II diabetes mellitus: a meta-analysis of placebo-controlled randomized trials. Int J Cardiol 2017;228:352-8. 10.1016/j.ijcard.2016.11.181 - DOI - PubMed
    1. Tang H, Fang Z, Wang T, et al. Meta-analysis of effects of sodium-glucose cotransporter 2 inhibitors on cardiovascular outcomes and all-cause mortality among patients with type 2 diabetes mellitus. Am J Cardiol 2016;118:1774-80. 10.1016/j.amjcard.2016.08.061 - DOI - PubMed
    1. Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 2017;377:644-57. 10.1056/NEJMoa1611925 - DOI - PubMed

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