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Comment
. 2017 Dec;5(23):479.
doi: 10.21037/atm.2017.09.02.

Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers

Bob T Li  1 , Dennis Stephens  1 , Jamie E Chaft  1 , Charles M Rudin  1 , David R Jones  2 , Valerie W Rusch  2 , Andreas Rimner  3 , James M Isbell  2
Affiliations
Comment

Liquid biopsy for ctDNA to revolutionize the care of patients with early stage lung cancers

Bob T Li et al. Ann Transl Med. 2017 Dec.

Abstract

The current standard of adjuvant therapies for patients with early stage non-small-cell lung cancers largely depends on the stage of disease. Liquid biopsy for circulating tumor DNA (ctDNA) has the potential to detect minimal residual disease, depict genomic evolution, guide precision medicine to individual patients and revolutionize the management of early stage lung cancers. In light of the seminal work published by Abbosh and colleagues, we discuss the potential paradigm changing clinical implications of ctDNA, the biological and technological challenges to consider, and the future of ctDNA driven therapeutic studies.

Keywords: Liquid biopsy; circulating tumor DNA (ctDNA); genetic sequencing; lung cancer.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
PA (A) and lateral (B) views of chest at radiation simulation with gross tumor volume in red, measured at 20.15 cm3. A biological question would be how much ctDNA shedding occurs from this lung adenocarcinoma, and technologically what is the best ctDNA assay to reliably detect it? ctDNA, circulating tumor DNA.
See this image and copyright information in PMC

Comment on

  • Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.
    Abbosh C, Birkbak NJ, Wilson GA, Jamal-Hanjani M, Constantin T, Salari R, Le Quesne J, Moore DA, Veeriah S, Rosenthal R, Marafioti T, Kirkizlar E, Watkins TBK, McGranahan N, Ward S, Martinson L, Riley J, Fraioli F, Al Bakir M, Grönroos E, Zambrana F, Endozo R, Bi WL, Fennessy FM, Sponer N, Johnson D, Laycock J, Shafi S, Czyzewska-Khan J, Rowan A, Chambers T, Matthews N, Turajlic S, Hiley C, Lee SM, Forster MD, Ahmad T, Falzon M, Borg E, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Hafez D, Naik A, Ganguly A, Kareht S, Shah R, Joseph L, Marie Quinn A, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Oukrif D, Akarca AU, Hartley JA, Lowe HL, Lock S, Iles N, Bell H, Ngai Y, Elgar G, Szallasi Z, Schwarz RF, Herrero J, Stewart A, Quezada SA, Peggs KS, Van Loo P, Dive C, Lin CJ, Rabinowitz M, Aerts HJWL, Hackshaw A, Shaw JA, Zimmermann BG; TRACERx consortium; PEACE consortium; Swanton C. Abbosh C, et al. Nature. 2017 Apr 26;545(7655):446-451. doi: 10.1038/nature22364. Nature. 2017. PMID: 28445469 Free PMC article.

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