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. 2018 Apr;22(4):512-519.
doi: 10.1007/s10995-017-2417-6.

Preeclampsia and Hypertension During Pregnancy in Areas with Relatively Low Levels of Traffic Air Pollution

Christian Madsen  1   2   3 , Siri Eldevik Håberg  4 , Geir Aamodt  5 , Hein Stigum  4   6 , Per Magnus  4 , Stephanie J London  7 , Wenche Nystad  4 , Per Nafstad  4   6
Affiliations

Preeclampsia and Hypertension During Pregnancy in Areas with Relatively Low Levels of Traffic Air Pollution

Christian Madsen et al. Matern Child Health J. 2018 Apr.

Abstract

Objectives Air pollution exposure may contribute to the development of preeclampsia and hypertension during pregnancy. However, the evidence for such a relation is still limited. We investigated the associations between exposure for moderate to low levels of air pollution during pregnancy and preeclampsia and gestational hypertension in selected urban and county areas of Norway. Methods This study used a sub-group of 17,533 women in the Norwegian Mother and Child Cohort Study. Air pollution levels at residential addresses were estimated using land use regression models and back-extrapolated to the period of each pregnancy. Information on preeclampsia and gestational hypertension were obtained from the Medical Birth Registry of Norway and information on lifestyle factors was collected from questionnaires completed by the women during pregnancy. Results Moderate mean levels of NO2 (13.6 ± 6.9 µg/m3) at residential address during pregnancy were not associated with preeclampsia and pregnancy hypertension. We found no statistically significant associations per 10 µg/m3 change in NO2 exposure and preeclampsia (adjusted OR 0.89, 95% CI 0.74, 1.08) or hypertension during pregnancy (adjusted OR 0.91, 95% CI 0.78, 1.06). Conclusions for Practice In this large Norwegian pregnancy cohort, we found no statistically significant associations for moderate to low levels of pregnancy NO2 exposure and preeclampsia or hypertension during pregnancy.

Keywords: Air pollution; NO2; Preeclampsia; Pregnancy hypertension; The Norwegian Mother and Child Cohort Study.

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Conflict of interest statement

Competing interests: none declared.

References

    1. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet. 2010;376(9741):631–644. - PubMed
    1. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365(9461):785–799. - PubMed
    1. Brook RD, Rajagopalan S, Pope CA, 3rd, Bhatnagar A, Diez-Roux AV, Holguin F, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331–2378. - PubMed
    1. van den Hooven EH, de Kluizenaar Y, Pierik FH, van Ratingen SW, Zandveld PY, Mackenbach JP, et al. Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study. Hypertension. 2011;57(3):406–412. - PubMed
    1. Malmqvist E, Jakobsson K, Tinnerberg H, Rignell-Hydbom A, Rylander L. Gestational diabetes and preeclampsia in association with air pollution at levels below current air quality guidelines. Environmental Health Perspectives. 2013;121(4):488–493. - PMC - PubMed

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