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. 2018 May-Jun;20(3):265-269.
doi: 10.4103/aja.aja_60_17.

Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma

Jin-You Wang  1 , Ming-Zhu Gao  2 , De-Xin Yu  1 , Dong-Dong Xie  1 , Yi Wang  1 , Liang-Kuan Bi  1 , Tao Zhang  1 , De-Mao Ding  1
Affiliations

Histological subtype is a significant predictor for inguinal lymph node metastasis in patients with penile squamous cell carcinoma

Jin-You Wang et al. Asian J Androl. 2018 May-Jun.

Abstract

The present study aimed to investigate the relationship between histopathological subtype and the probability of inguinal lymph node metastasis (ILNM) in patients with penile squamous cell carcinoma (PSCC). The clinical records of 198 consecutive patients with PSCC were analyzed retrospectively. Primary lesions were reevaluated according to the 2016 World Health Organization (WHO) histopathological classification. We retrieved the clinicopathological factors from the medical records including age, clinical lymph node stage, pathological tumor stage, lymphatic invasion, and nerve invasion. Uni- and multivariate logistic regression analyses were used to explore the risk factors of ILNM. Multivariate analyses identified clinical lymph node stage (P = 0.000), pathological tumor stage (P = 0.016), histologic grade (P = 0.000), and risk group of histological subtypes (P = 0.029) as independent predictors for ILNM. Compared with the low-risk group of PSCC subtypes, the intermediate- (HR: 3.66, 95% CI: 1.30-10.37, P = 0.021) and high-risk groups (HR: 28.74, 95% CI: 2.37-348.54, P = 0.008) were significantly associated with ILNM. In conclusion, the histopathological subtype of the primary lesion is a significant predictor for ILNM in patients with PSCC.

Keywords: histopathological subtype; inguinal lymph node metastasis; penile neoplasm; squamous cell carcinoma.

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References

    1. Forman D, Bray F, Brewster DH, Gombe Mbalawa C, Kohler B, et al. Lyon: International Agency for Research on Cancer; 2014. Cancer Incidence in Five Continents IARC Scientific Publication No 164 Vol X; pp. 1118–22.
    1. Barnholtz-Sloan JS, Maldonado JL, Pow-Sang J, Giuliano AR. Incidence trends in primary malignant penile cancer. Urol Oncol. 2007;25:361–7. - PubMed
    1. Harmaya A, Yudiana I, Oka A, Djatisoesanto W. Predictive factors of inguinal lymph node metastasis in men with penile cancer at Sanglah hospital, Denpasar, Bali. Jurnal Bedah Nasional (JBN) 2017;1:39–46.
    1. Graafland NM, van Boven HH, van Werkhoven E, Moonen LM, Horenblas S. Prognostic significance of extranodal extension in patients with pathological node positive penile carcinoma. J Urol. 2010;184:1347–53. - PubMed
    1. Lutzen U, Zuhayra M, Marx M, Zhao Y, Knupfer S, et al. Value and efficacy of sentinel lymph node diagnostics in patients with penile carcinoma with nonpalpable inguinal lymph nodes: five-year follow-up. Clin Nucl Med. 2016;41:621–5. - PubMed