Early and late radiation effects in healthy tissues of oncologic patients under therapeutic irradiations
- PMID: 29286495
Early and late radiation effects in healthy tissues of oncologic patients under therapeutic irradiations
Abstract
The objective of the article is summarize the literature regarding on the patterns and mechanisms of the formation of early and distant radiation reactions of healthy cells due to the therapeutic irradiation of cancer patients. Particular attention is given to the modern views on the molecular mechanisms of the processes of various repair systems (DDR, BER, NER, MMR, etc.) whose ineffectiveness is associated with radiation induced instability of the genome of healthy cells and the etiology of secondary tumours of radiation genesis in cancer patients as a result of radiation therapy. Solving the problem of individual radiation sensitivity of an organism of cancer patients will help to reduce the frequency of early and late radiation complications.
Tsel' obzora – obobshchenie dannykh literatury, kasaiushchikhsia zakonomernosteĭ i mekhanizmov formirovaniia ran nikh i otdalennykh luchevykh reaktsiĭ zdorovykh kletok vsledstvie terapevticheskogo oblucheniia onkologicheskikh bol'nykh. Osoboe vnimanie udeliaetsia sovremennym vzgliadam na molekuliarnye mekhanizmy protsessov razlich nykh sistem reparatsii (DDR, BER, NER, MMR i dr.), neéffektivnost' kotorykh sviazana s radiatsionno indutsiro vannoĭ nestabil'nost'iu genoma zdorovykh kletok, i étiologii vtorichnykh opukholeĭ radiatsionnogo geneza u on kologicheskikh bol'nykh vsledstvie luchevoĭ terapii. Reshenie problemy individual'noĭ radiatsionnoĭ chuvstvitel'nosti organizma onkologicheskikh bol'nykh budet sposobstvovat' snizheniiu chastoty rannikh i pozd nikh luchevykh oslozhneniĭ.
Keywords: healthy cell responses; oncologic patients; radiation therapy; secondary tumours; smoothing.
E. A. Domina.