Reply to Risk and Zhu: Mixed-effects modeling as a principled approach to heritability analysis with repeat measurements

Tian Ge^{1

2

3}, Avram J Holmes^{4

5

6}, Randy L Buckner^{4

6

7

8}, Jordan W Smoller^{2

3}, Mert R Sabuncu^{4

9

10}

Affiliations

¹ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; tge1@mgh.harvard.edu.
² Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
³ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138.
⁴ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.
⁵ Department of Psychology, Yale University, New Haven, CT 06520.
⁶ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
⁷ Department of Psychology, Harvard University, Cambridge, MA 02138.
⁸ Center for Brain Science, Harvard University, Cambridge, MA 02138.
⁹ School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853.
¹⁰ Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.

PMID: 29288224
PMCID: PMC5777085
DOI: 10.1073/pnas.1719882115

Comment

Reply to Risk and Zhu: Mixed-effects modeling as a principled approach to heritability analysis with repeat measurements

Tian Ge et al. Proc Natl Acad Sci U S A. 2018.

. 2018 Jan 9;115(2):E123.

doi: 10.1073/pnas.1719882115. Epub 2017 Dec 29.

Authors

Tian Ge^{1

2

3}, Avram J Holmes^{4

5

6}, Randy L Buckner^{4

6

7

8}, Jordan W Smoller^{2

3}, Mert R Sabuncu^{4

9

10}

Affiliations

¹ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; tge1@mgh.harvard.edu.
² Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
³ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138.
⁴ Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129.
⁵ Department of Psychology, Yale University, New Haven, CT 06520.
⁶ Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.
⁷ Department of Psychology, Harvard University, Cambridge, MA 02138.
⁸ Center for Brain Science, Harvard University, Cambridge, MA 02138.
⁹ School of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853.
¹⁰ Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.

PMID: 29288224
PMCID: PMC5777085
DOI: 10.1073/pnas.1719882115

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

Heritability analysis with repeat measurements and its application to resting-state functional connectivity.
Ge T, Holmes AJ, Buckner RL, Smoller JW, Sabuncu MR. Ge T, et al. Proc Natl Acad Sci U S A. 2017 May 23;114(21):5521-5526. doi: 10.1073/pnas.1700765114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28484032 Free PMC article.
Note on bias from averaging repeated measurements in heritability studies.
Risk BB, Zhu H. Risk BB, et al. Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E122. doi: 10.1073/pnas.1719250115. Epub 2017 Dec 29. Proc Natl Acad Sci U S A. 2018. PMID: 29288225 Free PMC article. No abstract available.

References

1. Ge T, Holmes AJ, Buckner RL, Smoller JW, Sabuncu MR. Heritability analysis with repeat measurements and its application to resting-state functional connectivity. Proc Natl Acad Sci USA. 2017;114:5521–5526. - PMC - PubMed
1. Risk BB, Zhu H. Note on bias from averaging repeated measurements in heritability studies. Proc Natl Acad Sci USA. 2018;115:E122. - PMC - PubMed

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Reply to Risk and Zhu: Mixed-effects modeling as a principled approach to heritability analysis with repeat measurements

Affiliations

Reply to Risk and Zhu: Mixed-effects modeling as a principled approach to heritability analysis with repeat measurements

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

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