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. 2017 Dec 29;7(12):e018544.
doi: 10.1136/bmjopen-2017-018544.

Pharmacological interventions for preventing post-operative atrial fibrillation in patients undergoing cardiac surgery: a network meta-analysis protocol

Xiaoqin Wang  1   2   3 , Liang Yao  4 , Long Ge  1   2   3 , Lun Li  5 , Fuxiang Liang  6 , Qi Zhou  6 , Yaolong Chen  1   2   3 , Yongfeng Wang  7 , Kehu Yang  1   2   3
Affiliations

Pharmacological interventions for preventing post-operative atrial fibrillation in patients undergoing cardiac surgery: a network meta-analysis protocol

Xiaoqin Wang et al. BMJ Open. .

Abstract

Introduction: Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery, and randomised clinical trials (RCTs) and systematic reviews have been conducted to compare and evaluate different pharmacological interventions for preventing POAF. This study aimed to explore the effect of different pharmacological interventions for prophylaxis against POAF after cardiac surgery using network meta-analysis (NMA).

Methods and analysis: A systematic search will be performed in PubMed, EMBASE and the Cochrane Library to identify RCTs, systematic reviews, meta-analyses or NMA of different pharmacological interventions for POAF. We will evaluate the risk of bias of the included RCTs according to the Cochrane Handbook V.5.1.0, and use GRADE to assess the quality of evidence. Standard pairwise meta-analysis, trial sequential analysis and Bayesian network meta-analysis will be used to compare the efficacy of different pharmacological interventions.

Ethics and dissemination: Ethics approval and patient consent are not required as this study is a meta-analysis based on published studies. The results of this NMA and trial sequential analysis will be submitted to a peer-reviewed journal for publication.

Protocol registration number: CRD42017067492.

Keywords: network meta-analysis; pharmacological interventions; postoperative atrial fibrillation (poaf); prevention.

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Conflict of interest statement

Competing interests: None declared.

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References

    1. Echahidi N, Pibarot P, O’Hara G, et al. . Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery. J Am Coll Cardiol 2008;51:793–801. 10.1016/j.jacc.2007.10.043 - DOI - PubMed
    1. Jongnarangsin K, Oral H. Postoperative atrial fibrillation. Cardiol Clin 2009;27:69–78. 10.1016/j.ccl.2008.09.011 - DOI - PubMed
    1. Nair SG. Atrial fibrillation after cardiac surgery. Ann Card Anaesth 2010;13:196–205. 10.4103/0971-9784.69047 - DOI - PubMed
    1. Chelazzi C, Villa G, De Gaudio AR, et al. . Postoperative atrial fibrillation. ISRN Cardiol 2011;2011:1–10. 10.5402/2011/203179 - DOI - PMC - PubMed
    1. Raiten JM, Ghadimi K, Augoustides JG, et al. . Atrial fibrillation after cardiac surgery: clinical update on mechanisms and prophylactic strategies. J Cardiothorac Vasc Anesth 2015;29:806–16. 10.1053/j.jvca.2015.01.001 - DOI - PubMed

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