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Editorial
. 2017 Nov 23;8(1):1407203.
doi: 10.1080/20010001.2017.1407203. eCollection 2018.

Testing drug combinations to slow aging

Warren Ladiges  1 , Denny Liggitt  1
Affiliations
Editorial

Testing drug combinations to slow aging

Warren Ladiges et al. Pathobiol Aging Age Relat Dis. .
No abstract available

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
Slowing aging might best be achieved by drug combinations that target multiple interactive molecular pathways. However, very little testing of drug combinations has been done because of a lack of preclinical screening paradigms. This figure demonstrates how the interaction of a prototype drug combination, rapamycin, acarbose, and SS31, can be tested for anti-aging effects in a preclinical setting using the aged mouse and a geropathology grading system.
See this image and copyright information in PMC

References

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    1. Wilkinson JE, Burmeister L, Brooks SV, et al. Rapamycin slows aging in mice. Aging Cell. 2012. August;11(4):675–3. - PMC - PubMed
    1. Flynn JM, O’Leary MN, Zambataro CA, et al. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell. 2013. October;12(5):851–862. Epub 2013 Jul 7. - PMC - PubMed
    1. Harrison DE, Strong R, Allison DB, et al. Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell. 2014. April;13(2):273–282. - PMC - PubMed
    1. Dai DF, Chen T, Szeto H, et al. Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy. J Am Coll Cardiol. 2011. June 28;58(1):73–82. - PMC - PubMed

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