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. 2017 Dec 5:8:101.
doi: 10.4103/ijpvm.IJPVM_246_16. eCollection 2017.

Alloimmunization in Thalassemia Patients: New Insight for Healthcare

Ali Davoudi-Kiakalayeh  1   2 , Reza Mohammadi  2 , Ali Akbar Pourfathollah  1 , Zahra Siery  1 , Sajad Davoudi-Kiakalayeh  3
Affiliations

Alloimmunization in Thalassemia Patients: New Insight for Healthcare

Ali Davoudi-Kiakalayeh et al. Int J Prev Med. .

Abstract

Background: Development of alloantibodies against the foreign red blood cell (RBC) (alloimmunization) is a well-known complication in thalassemia patients when performing multiple transfusions. The study was conducted to know the prevalence of alloimmunization in thalassemia patients, in the Caspian Sea coastline.

Methods: This study is a descriptive, retrospective analysis of transfusion records of 190 patients with β-thalassemia major who received regular transfusions. To detect the type of alloantibodies, two cells panel tests (kits; Iranian Blood Transfusion Organization [IBTO], 3 RBC cells and IBTO, 11 RBC cells) were used.

Results: Forty-seven patients were positive for alloantibodies (24.7%). Of them, 18.4% (35 cases) had only one alloantibody, and 6.3% (12 cases) had at least two or more of alloantibodies. The vast majority of alloantibodies were anti-Kell followed by anti-E, and anti-D, respectively.

Conclusions: Blood matching for Rh and K antigens in patients with transfusion-dependent thalassemia could reduce the rate of RBC alloinununization.

Keywords: Alloantibody; Iran; blood transfusion; thalassemia.

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Conflict of interest statement

There are no conflicts of interest.

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