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Comment
. 2018 Jan;93(1):22-24.
doi: 10.1016/j.kint.2017.07.008.

SGLT2 inhibitor empagliflozin: finally at the latter stage of understanding?

Gary C W Chan  1 , Sydney C W Tang  2
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SGLT2 inhibitor empagliflozin: finally at the latter stage of understanding?

Gary C W Chan et al. Kidney Int. 2018 Jan.
Free article

Abstract

Sodium glucose cotransporter 2 inhibitors are a relatively new adjunctive treatment option for type 2 diabetes (T2D). Extraglycemic benefits of sodium glucose cotransporter 2 inhibition include weight and blood pressure reduction. Cherney et al. now demonstrate that these extraglycemic properties of empagliflozin are preserved despite reduced urinary glucose excretion in advancing chronic kidney disease. Limited therapeutic options for patients with type 2 diabetes in the latter stages of chronic kidney disease make empagliflozin an attractive therapeutic agent with additional cardiovascular benefits.

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