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. 2018 Feb 1;596(3):351-353.
doi: 10.1113/JP274945. Epub 2018 Jan 2.

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

Lasse K Bak  1 , Anne B Walls  1
Affiliations

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

Lasse K Bak et al. J Physiol. .
No abstract available

Keywords: Astrocyte; Lactate; Neuron.

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Comment in

  • Rebuttal from L. F. Barros and B. Weber.
    Barros LF, Weber B. Barros LF, et al. J Physiol. 2018 Feb 1;596(3):355-356. doi: 10.1113/JP275506. Epub 2018 Jan 2. J Physiol. 2018. PMID: 29292518 Free PMC article. No abstract available.

References

    1. Bak LK & Schousboe A (2017). Misconceptions regarding basic thermodynamics and enzyme kinetics have led to erroneous conclusions regarding the metabolic importance of lactate dehydrogenase isoenzyme expression. J Neurosci Res 95, 2098–2102. - PubMed
    1. Bak LK, Schousboe A, Sonnewald U & Waagepetersen HS (2006). Glucose is necessary to maintain neurotransmitter homeostasis during synaptic activity in cultured glutamatergic neurons. J Cereb Blood Flow Metab 26, 1285–1297. - PubMed
    1. Bak LK, Walls AB, Schousboe A, Ring A, Sonnewald U & Waagepetersen HS (2009). Neuronal glucose but not lactate utilization is positively correlated with NMDA‐induced neurotransmission and fluctuations in cytosolic Ca2+ levels. J Neurochem 109, 87–93. - PubMed
    1. Bittar PG, Charnay Y, Pellerin L, Bouras C & Magistretti PJ (1996). Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain. J Cereb Blood Flow Metab 16, 1079–1089. - PubMed
    1. Bouzier‐Sore AK, Voisin P, Canioni P, Magistretti PJ & Pellerin L (2003). Lactate is a preferential oxidative energy substrate over glucose for neurons in culture. J Cereb Blood Flow Metab 23, 1298–1306. - PubMed

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