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. 2017 Dec 8;22(12):2176.
doi: 10.3390/molecules22122176.

Chemical Constituents from Euphorbia kansui

Qiao Zhang  1 , Qin-Rong Zhou  2 , Jian-Wei Lou  3 , Pei-Dong Chen  4 , Wei-Feng Yao  5 , Wei-Wei Tao  6 , Yu-Ping Tang  7 , Guan-Cheng Dai  8 , Kun Wang  9 , Li Zhang  10
Affiliations

Chemical Constituents from Euphorbia kansui

Qiao Zhang et al. Molecules. .

Abstract

In this research, a new triterpenoid, tirucalla-8,24-diene-3β,11β-diol-7-one (1), and eupha-8,24-diene-3β,11β-diol-7-one (2), which was isolated from Euphorbia kansui for the first time, together with twelve other known compounds (3-14), were isolated from the ethyl acetate extract of Euphorbia kansui. Their structures were elucidated based on High resolution electrospray ionization mass spectrometry (HR-ESI-MS), Infrared Spectroscopy (IR), 1D and 2D Nuclear Magnetic Resonance (NMR) data. Both constituents 1 and 2 exhibited moderate cytotoxicity against colon cancer HCT-116, gastric cancer MKN-45 and breast cancer MCF-7.

Keywords: Euphane and Tirucallane; Euphorbia kansui; cytotoxicity; triterpenes.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Chemical structures of Compounds 1–14.
Figure 2
Figure 2
Key NOESY correlations for 1 and 2.
Figure 3
Figure 3
Key HMBC correlations for 1 and 2.
See this image and copyright information in PMC

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