Review

. 2017 Dec 8;18(12):2659.

doi: 10.3390/ijms18122659.

LncRNA Structural Characteristics in Epigenetic Regulation

Chenguang Wang^{1

2}, Lianzong Wang^{3

4}, Yu Ding^{5

6}, Xiaoyan Lu^{7

8}, Guosi Zhang^{9

10}, Jiaxin Yang^{11

12}, Hewei Zheng^{13

14}, Hong Wang^{15

16}, Yongshuai Jiang^{17

18}, Liangde Xu^{19

20}

Affiliations

¹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wangcg@hrbmu.edu.cn.
² Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. wangcg@hrbmu.edu.cn.
³ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wanglz@hrbmu.edu.cn.
⁴ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. wanglz@hrbmu.edu.cn.
⁵ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. dingyu@hrbmu.edu.cn.
⁶ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. dingyu@hrbmu.edu.cn.
⁷ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. luxy@hrbmu.edu.cn.
⁸ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. luxy@hrbmu.edu.cn.
⁹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. zhanggs@hrbmu.edu.cn.
¹⁰ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. zhanggs@hrbmu.edu.cn.
¹¹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. yangjx@hrbmu.edu.cn.
¹² Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. yangjx@hrbmu.edu.cn.
¹³ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. zhenghw@hrbmu.edu.cn.
¹⁴ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. zhenghw@hrbmu.edu.cn.
¹⁵ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wanghong84@ems.hrbmu.edu.cn.
¹⁶ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. wanghong84@ems.hrbmu.edu.cn.
¹⁷ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. jiangyongshuai@ems.hrbmu.edu.cn.
¹⁸ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. jiangyongshuai@ems.hrbmu.edu.cn.
¹⁹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. xuliangde@hrbmu.edu.cn.
²⁰ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. xuliangde@hrbmu.edu.cn.

PMID: 29292750
PMCID: PMC5751261
DOI: 10.3390/ijms18122659

Review

LncRNA Structural Characteristics in Epigenetic Regulation

Chenguang Wang et al. Int J Mol Sci. 2017.

. 2017 Dec 8;18(12):2659.

doi: 10.3390/ijms18122659.

Authors

Affiliations

¹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wangcg@hrbmu.edu.cn.
² Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. wangcg@hrbmu.edu.cn.
³ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wanglz@hrbmu.edu.cn.
⁴ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. wanglz@hrbmu.edu.cn.
⁵ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. dingyu@hrbmu.edu.cn.
⁶ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. dingyu@hrbmu.edu.cn.
⁷ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. luxy@hrbmu.edu.cn.
⁸ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. luxy@hrbmu.edu.cn.
⁹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. zhanggs@hrbmu.edu.cn.
¹⁰ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. zhanggs@hrbmu.edu.cn.
¹¹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. yangjx@hrbmu.edu.cn.
¹² Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. yangjx@hrbmu.edu.cn.
¹³ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. zhenghw@hrbmu.edu.cn.
¹⁴ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. zhenghw@hrbmu.edu.cn.
¹⁵ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. wanghong84@ems.hrbmu.edu.cn.
¹⁶ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. wanghong84@ems.hrbmu.edu.cn.
¹⁷ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. jiangyongshuai@ems.hrbmu.edu.cn.
¹⁸ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. jiangyongshuai@ems.hrbmu.edu.cn.
¹⁹ College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China. xuliangde@hrbmu.edu.cn.
²⁰ Training Center for Students Innovation and Entrepreneurship Education, Harbin Medical University, Harbin 150081, China. xuliangde@hrbmu.edu.cn.

PMID: 29292750
PMCID: PMC5751261
DOI: 10.3390/ijms18122659

Abstract

The rapid development of new generation sequencing technology has deepened the understanding of genomes and functional products. RNA-sequencing studies in mammals show that approximately 85% of the DNA sequences have RNA products, for which the length greater than 200 nucleotides (nt) is called long non-coding RNAs (lncRNA). LncRNAs now have been shown to play important epigenetic regulatory roles in key molecular processes, such as gene expression, genetic imprinting, histone modification, chromatin dynamics, and other activities by forming specific structures and interacting with all kinds of molecules. This paper mainly discusses the correlation between the structure and function of lncRNAs with the recent progress in epigenetic regulation, which is important to the understanding of the mechanism of lncRNAs in physiological and pathological processes.

Keywords: RNA-protein binding motif; epigenetic regulation; lncRNA structure; regulation protein recruit.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
LncRNA architecture in complex transcriptional region.

**Figure 2**
The models of LncRNA structure mediated epigenetic regulation. (A) LncRNA allostery effect for interacting with different ligand proteins. (B) LncRNA acting as molecular scaffold to recruit and combine with multiple regulatory proteins. (C) LncRNA mediating histone modification by the functional region repeat elements.

See this image and copyright information in PMC

References

1. Schmitt A.M., Garcia J.T., Hung T., Flynn R.A., Shen Y., Qu K., Payumo A.Y., Peres-da-Silva A., Broz D.K., Baum R., et al. An inducible long noncoding RNA amplifies DNA damage signaling. Nat. Genet. 2016;48:1370–1376. doi: 10.1038/ng.3673. - DOI - PMC - PubMed
1. Rabani M., Raychowdhury R., Jovanovic M., Rooney M., Stumpo D.J., Pauli A., Hacohen N., Schier A.F., Blackshear P.J., Friedman N., et al. High-resolution sequencing and modeling identifies distinct dynamic RNA regulatory strategies. Cell. 2014;159:1698–1710. doi: 10.1016/j.cell.2014.11.015. - DOI - PMC - PubMed
1. Wu J., Liu Q., Wang X., Zheng J., Wang T., You M., Sheng Sun Z., Shi Q. mirTools 2.0 for non-coding RNA discovery, profiling, and functional annotation based on high-throughput sequencing. RNA Biol. 2013;10:1087–1092. doi: 10.4161/rna.25193. - DOI - PMC - PubMed
1. Lee J.T. Epigenetic regulation by long noncoding RNAs. Science. 2012;338:1435–1439. doi: 10.1126/science.1231776. - DOI - PubMed
1. Bu D., Yu K., Sun S., Xie C., Skogerbo G., Miao R., Xiao H., Liao Q., Luo H., Zhao G., et al. NONCODE v3.0: Integrative annotation of long noncoding RNAs. Nucleic Acids Res. 2012;40:D210–D215. doi: 10.1093/nar/gkr1175. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Research Materials
- NCI CPTC Antibody Characterization Program

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

LncRNA Structural Characteristics in Epigenetic Regulation

Affiliations

LncRNA Structural Characteristics in Epigenetic Regulation

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials