Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Feb 1;21(2):154-156.
doi: 10.1093/ijnp/pyx120.

Is Metabolism of (R)-Ketamine Essential for the Antidepressant Effects?

Shigeyuki Chaki  1
Affiliations
Comment

Is Metabolism of (R)-Ketamine Essential for the Antidepressant Effects?

Shigeyuki Chaki. Int J Neuropsychopharmacol. .
No abstract available

Keywords: (2R,6R)-hydroxynorketamine; (R)-ketamine; (R)-norketamine; antidepressant; ketamine.

PubMed Disclaimer

Comment on

References

    1. Ardalan M, Wegener G, Rafati AH, Nyengaard JR(2017)S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression. Int J Neuropsychopharmacol 20:247–256. - PMC - PubMed
    1. Belujon P, Grace AA(2014)Restoring mood balance in depression: ketamine reverses deficit in dopamine-dependent synaptic plasticity. Biol Psychiatry 76:927–936. - PMC - PubMed
    1. Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH(2000)Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351–354. - PubMed
    1. Carreno FR, Donegan JJ, Boley AM, Shah A, DeGuzman M, Frazer A, Lodge DJ(2016)Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine. Mol Psychiatry 21:1298–1308. - PubMed
    1. Chaki S.(2017)Beyond ketamine: new approaches to the development of safer antidepressants. Curr Neuropharmacol 15:963–976. - PMC - PubMed