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Review
. 2018 Aug 2;20(9):1162-1172.
doi: 10.1093/neuonc/nox242.

The FDA NIH Biomarkers, EndpointS, and other Tools (BEST) resource in neuro-oncology

Daniel N Cagney  1 , Joohee Sul  2 , Raymond Y Huang  3 , Keith L Ligon  4 , Patrick Y Wen  5 , Brian M Alexander  1
Affiliations
Review

The FDA NIH Biomarkers, EndpointS, and other Tools (BEST) resource in neuro-oncology

Daniel N Cagney et al. Neuro Oncol. .

Abstract

In early 2016, the FDA and the National Institutes of Health (NIH) published the first version of the glossary included in the Biomarkers, EndpointS, and other Tools (BEST) resource.1 The BEST glossary was constructed to harmonize and clarify terms used in translational science and medical product development and to provide a common language used for communication by those agencies. It is considered a "living" document that will be updated in the future. This review will discuss the main biomarker and clinical outcome categories contained in the BEST glossary as they apply to neuro-oncology, as well as the overlapping and hierarchical relationships among them.

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Figures

Fig. 1
Fig. 1
Biomarkers along the clinical continuum.
See this image and copyright information in PMC

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