Human T-cell immunity against the emerging and re-emerging viruses

doi:10.1007/s11427-017-9241-3

Review

. 2017 Dec;60(12):1307-1316.

doi: 10.1007/s11427-017-9241-3. Epub 2017 Nov 29.

Human T-cell immunity against the emerging and re-emerging viruses

Min Zhao¹, Hangjie Zhang², Kefang Liu², George F Gao^{1

2

3}, William J Liu⁴

Affiliations

¹ Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.
² Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
³ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. liujun@ivdc.chinacdc.cn.

PMID: 29294219
PMCID: PMC7089170
DOI: 10.1007/s11427-017-9241-3

Review

Human T-cell immunity against the emerging and re-emerging viruses

Min Zhao et al. Sci China Life Sci. 2017 Dec.

. 2017 Dec;60(12):1307-1316.

doi: 10.1007/s11427-017-9241-3. Epub 2017 Nov 29.

Authors

Min Zhao¹, Hangjie Zhang², Kefang Liu², George F Gao^{1

2

3}, William J Liu⁴

Affiliations

¹ Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China.
² Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
³ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. liujun@ivdc.chinacdc.cn.

PMID: 29294219
PMCID: PMC7089170
DOI: 10.1007/s11427-017-9241-3

Abstract

Over the past decade, we have seen an alarming number of high-profile outbreaks of newly emerging and re-emerging viruses. Recent outbreaks of avian influenza viruses, Middle East respiratory syndrome coronaviruses, Zika virus and Ebola virus present great threats to global health. Considering the pivotal role of host T-cell immunity in the alleviation of symptoms and the clearance of viruses in patients, there are three issues to be primarily concerned about T-cell immunity when a new virus emerges: first, does the population possess pre-existing T-cells against the new virus through previous infections of genetically relevant viruses; second, does a proper immune response arise in the patients to provide protection through an immunopathogenic effect; lastly, how long can the virus-specific immune memory persist. Herein, we summarize the current updates on the characteristics of human T-cell immunological responses against recently emerged or re-emerged viruses, and emphasize the necessity for timely investigation on the T-cell features of these viral diseases, which may provide beneficial recommendations for clinical diagnosis and vaccine development.

Keywords: Ebola; H7N9; MERS-CoV; T-cell; Zika; avian influenza; cross-reactivity; emerging viruses; human immunity.

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References

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[1] Al-Qahtani A.A., Lyroni K., Aznaourova M., Tseliou M., Al-Anazi M. R., Al-Ahdal M.N., Alkahtani S., Sourvinos G., Tsatsanis C. Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARgamma. Oncotarget. 2017;8:9053–9066. - PMC - PubMed

[2] Al-Qahtani A.A., Lyroni K., Aznaourova M., Tseliou M., Al-Anazi M. R., Al-Ahdal M.N., Alkahtani S., Sourvinos G., Tsatsanis C. Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARgamma. Oncotarget. 2017;8:9053–9066. - PMC - PubMed

[3] Assiri A., Al-Tawfiq J.A., Al-Rabeeah A.A., Al-Rabiah F.A., Al-Hajjar S., Al-Barrak A., Flemban H., Al-Nassir W.N., Balkhy H.H., Al-Hakeem R.F., Makhdoom H.Q., Zumla A.I., Memish Z.A. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13:752–761. doi: 10.1016/S1473-3099(13)70204-4. - DOI - PMC - PubMed

[4] Assiri A., Al-Tawfiq J.A., Al-Rabeeah A.A., Al-Rabiah F.A., Al-Hajjar S., Al-Barrak A., Flemban H., Al-Nassir W.N., Balkhy H.H., Al-Hakeem R.F., Makhdoom H.Q., Zumla A.I., Memish Z.A. Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis. 2013;13:752–761. doi: 10.1016/S1473-3099(13)70204-4. - DOI - PMC - PubMed

[5] Baize S., Leroy E.M., Georges-Courbot M.C., Capron M., Lansoud-Soukate J., Debré P., Fisher-Hoch S.P., McCormick J.B., Georges A.J. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat Med. 1999;5:423–426. doi: 10.1038/7422. - DOI - PubMed

[6] Baize S., Leroy E.M., Georges-Courbot M.C., Capron M., Lansoud-Soukate J., Debré P., Fisher-Hoch S.P., McCormick J.B., Georges A.J. Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. Nat Med. 1999;5:423–426. doi: 10.1038/7422. - DOI - PubMed

[7] Baize S., Pannetier D., Oestereich L., Rieger T., Koivogui L., Magassouba N.F., Soropogui B., Sow M.S., Keïta S., De Clerck H., Tiffany A., Dominguez G., Loua M., Traoré A., Kolié M., Malano E.R., Heleze E., Bocquin A., Mély S., Raoul H., Caro V., Cadar D., Gabriel M., Pahlmann M., Tappe D., Schmidt-Chanasit J., Impouma B., Diallo A.K., Formenty P., Van Herp M., Günther S. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371:1418–1425. doi: 10.1056/NEJMoa1404505. - DOI - PubMed

[8] Baize S., Pannetier D., Oestereich L., Rieger T., Koivogui L., Magassouba N.F., Soropogui B., Sow M.S., Keïta S., De Clerck H., Tiffany A., Dominguez G., Loua M., Traoré A., Kolié M., Malano E.R., Heleze E., Bocquin A., Mély S., Raoul H., Caro V., Cadar D., Gabriel M., Pahlmann M., Tappe D., Schmidt-Chanasit J., Impouma B., Diallo A.K., Formenty P., Van Herp M., Günther S. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371:1418–1425. doi: 10.1056/NEJMoa1404505. - DOI - PubMed

[9] Bardina S.V., Bunduc P., Tripathi S., Duehr J., Frere J.J., Brown J.A., Nachbagauer R., Foster G.A., Krysztof D., Tortorella D., Stramer S. L., García-Sastre A., Krammer F., Lim J.K. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 2017;356:175–180. doi: 10.1126/science.aal4365. - DOI - PMC - PubMed

[10] Bardina S.V., Bunduc P., Tripathi S., Duehr J., Frere J.J., Brown J.A., Nachbagauer R., Foster G.A., Krysztof D., Tortorella D., Stramer S. L., García-Sastre A., Krammer F., Lim J.K. Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. Science. 2017;356:175–180. doi: 10.1126/science.aal4365. - DOI - PMC - PubMed

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Human T-cell immunity against the emerging and re-emerging viruses

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Human T-cell immunity against the emerging and re-emerging viruses

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