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Review
. 2017 Sep 20;35(9):668-672.
doi: 10.3760/cma.j.issn.1001-9391.2017.09.006.

[Study of the association between interleukin-1 polymorphisms and genetic susceptibility of coal workers' pneumoconiosis and silicosis]

[Article in Chinese]
W Wang  1 , W H Zhang, Y S Tao, X Zhuang, M J Chu
Affiliations
Review

[Study of the association between interleukin-1 polymorphisms and genetic susceptibility of coal workers' pneumoconiosis and silicosis]

[Article in Chinese]
W Wang et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. .

Abstract
in English, Chinese

Objective: To evaluate the relationship between IL-1 gene polymorphisms and coal workers' pneumoconiosis and silicosis susceptibility. Methods: We searched published full-text from PubMed, Web of Science, CNKI, VIP and Wanfang to collect case-control study on IL-1 gene polymorphisms with coal workers' pneumoconiosis and silicosis susceptibility. Eight articles, including 10 case-control studies were included in our study. All analyses were performed using the Stata version 12.0 software. Results: The IL-1RA (+2018) TC or CC variant genotypes were associated with coal workers' pneumoconiosis and silicosis risk (OR=1.65, 95%CI: 1.11-2.46) . In further stratified analyses, the IL-1RA (+2018) TC or CC variant genotypes were associated with an increased silicosis risk (OR=2.07, 95%CI: 1.45-2.95) , which were also associated with increased coal workers' pneumoconiosis and silicosis risk in Caucasians (OR=1.74, 95%CI: 1.22-2.47) . No significant association between IL-1β (+3953) , IL-1β (-511) , IL-1α (+4845) and coal workers' pneumoconiosis and silicosis risk was found either in the overall study or in the stratified analysis. Conclusion: These findings suggested that IL-1RA (+2018) may modify coal workers' pneumoconiosis and silicosis susceptibility. Further replication studies with large sample sizes are warranted to re-evaluate the relationship between IL-1RA (+2018) and coal workers' pneumoconiosis and silicosis risk.

目的： 评价白细胞介素-1（interleukin-1，IL-1）基因遗传变异与煤工尘肺及矽肺易感性的关联。 方法： 检索PubMed、Web of Science、中国期刊全文数据库、维普数据库和万方数据库，收集国内外公开发表的关于IL-1基因多态性与煤工尘肺及矽肺易感性研究的文献，收集IL-1基因遗传变异与煤工尘肺及矽肺易感性的病例对照研究，最终共8篇文献包含10项病例-对照研究纳入分析。应用Stata12.0软件进行统计分析。 结果： Meta分析结果显示IL-1RA（+2018）TC或CC危险等位基因型与煤工尘肺及矽肺总的发病风险相关（OR=1.65，95%CI：1.11~2.46）。进一步分层分析结果显示，IL-1RA（+2018）TC或CC危险等位基因型能增加矽肺发病风险（OR=2.07，95%CI：1.45~2.95），同时还能增加高加索人群煤工尘肺及矽肺总的发病风险（OR=1.74，95%CI：1.22~2.47）。对于本次研究纳入分析的IL-1β（+3953）、IL-1β（-511）、IL-1α（+4845），无论是总的研究还是分层分析，均未发现相关遗传变异与煤工尘肺及矽肺发病风险明显关联。 结论： IL-1RA（+2018）多态位点与煤工尘肺及矽肺总的发病风险相关，后续仍需要进行更大样本量的人群验证。.

Keywords: Interleukin-1; Meta-analysis; Pneumoconiosis; Polymorphism, signle nucleotide; Silicosis.

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