Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Dec 23;10(1):9.
doi: 10.3390/nu10010009.

Nutrition and Liver Disease

Claudia Mandato  1 , Antonella Di Nuzzi  2 , Pietro Vajro  3
Affiliations
Editorial

Nutrition and Liver Disease

Claudia Mandato et al. Nutrients. .

Abstract

Malnutrition in children and adults with advanced liver disease represents a tremendous challenge as the nutritional problems are multifactorial. This Editorial comments the articles appearing in this special issue of Nutrients, "Nutrition and Liver disease" dealing with multiple diagnostic and therapeutic features that relate the outcomes of liver disease to nutrition. To improve quality of life and prevent nutrition-related medical complications, patients diagnosed with advanced liver disease should have their nutritional status promptly assessed and be supported by appropriate dietary interventions. Furthermore specific food supplements and/or restriction diets are often necessary for those with hepatic conditions associated with an underlying metabolic or nutritional or intestinal disease.

Keywords: assessment; cholestasis; liver disease; liver transplantation; nutrition; support.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Diagnostic and therapeutic issues that link outcomes of liver diseases to nutrition.
Figure 2
Figure 2
Gut-liver axis and liver diseases. Increased intestinal permeability and dysbiosis are common features linking the liver to a number of nutritional/gastrointestinal (GI) diseases depicted in the figure. The toll-like receptor (TLR)–bacterial lipopolysaccharide (LPS) interaction is one of the mechanisms involved in the release of proinflammatory mediators (cytokines), leading to liver inflammation and stellate-cell-activation-dependent fibrosis. Emerging therapeutic approaches that target the gut-liver axis therefore represent promising therapies to prevent or halt liver disease progression.
See this image and copyright information in PMC

References

    1. Imai K., Takai K., Watanabe S., Hanai T., Suetsugu A., Shiraki M., Shimizu M. Sarcopenia Impairs Prognosis of Patients with Hepatocellular Carcinoma: The Role of Liver Functional Reserve and Tumor-Related Factors in Loss of Skeletal Muscle. Nutrients. 2017;9:1054. doi: 10.3390/nu9101054. - DOI - PMC - PubMed
    1. Nishikawa H., Nishimura T., Enomoto H., Iwata Y., Ishii A., Miyamoto Y., Ishii N., Yuri Y., Takata R., Hasegawa K., et al. Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases. Nutrients. 2017;9:620. doi: 10.3390/nu9060620. - DOI - PMC - PubMed
    1. Yoh K., Nishikawa H., Enomoto H., Ishii A., Iwata Y., Miyamoto Y., Ishii N., Yuri Y., Hasegawa K., Nakano C., et al. Predictors Associated with Increase in Skeletal Muscle Mass after Sustained Virological Response in Chronic Hepatitis C Treated with Direct Acting Antivirals. Nutrients. 2017;9:1135. doi: 10.3390/nu9101135. - DOI - PMC - PubMed
    1. Amodio P., Bemeur C., Butterworth R., Cordoba J., Kato A., Montagnese S., Uribe M., Vilstrup H., Morgan M.Y. The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus. Hepatology. 2013;58:325–336. doi: 10.1002/hep.26370. - DOI - PubMed
    1. Leong D.P., Teo K.K., Rangarajan S., Lopez-Jaramillo P., Avezum A., Jr., Orlandini A., Seron P., Ahmed S.H., Rosengren A., Kelishadi R., et al. Prognostic value of grip strength: Findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet. 2015;386:266–273. doi: 10.1016/S0140-6736(14)62000-6. - DOI - PubMed

Publication types

LinkOut - more resources