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. 2018 Feb 1;28(3):529-532.
doi: 10.1016/j.bmcl.2017.11.012. Epub 2017 Nov 7.

Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

Suvarna H Pagire  1 , Eunhye Lee  2 , Haushabhau S Pagire  1 , Eun Jung Bae  1 , Soo Jung Ryu  1 , Dahye Lee  1 , Min Hee Kim  1 , Geum Ran Kim  3 , Kyu-Seok Hwang  3 , Sukyung Ahn  2 , Jin Hee Maeng  2 , Jin Sook Song  3 , Myung Ae Bae  3 , Don Hang Lee  2 , Jin Hee Ahn  4
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Design, synthesis and biological evaluation of glutamic acid derivatives as anti-oxidant and anti-inflammatory agents

Suvarna H Pagire et al. Bioorg Med Chem Lett. .

Abstract

A series of glutamic acid derivatives was synthesized and evaluated for their antioxidant activity and stability. We found several potent and stable glutamic acid derivatives. Among them, compound 12b exhibited good in vitro activity, chemical stability and cytotoxicity. A prototype compound 12b showed an anti-inflammatory effect in LPS-stimulated RAW 264.7 cell lines and in a zebrafish model.

Keywords: Antioxidant; Glutamic acid derivatives; Ramalin.

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