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. 2016;4(2):133-144.

Stereotactic body radiotherapy for primary and metastatic liver tumors - the Mayo Clinic experience

Kenneth W Merrell  1 , Jedediah E Johnson  1 , Benjamin Mou  1 , Brandon M Barney  1 , Kathryn E Nelson  1 , Charles S Mayo  1 , Michael G Haddock  1 , Christopher L Hallemeier  1 , Kenneth R Olivier  1
Affiliations

Stereotactic body radiotherapy for primary and metastatic liver tumors - the Mayo Clinic experience

Kenneth W Merrell et al. J Radiosurg SBRT. 2016.

Abstract

Introduction: To better understand the efficacy of liver SBRT we reviewed our prospectively collected institutional SBRT database.

Methods: Between May 2008 and March 2013, 80 patients with 104 liver lesions received SBRT. The Kaplan-Meier method estimated local control (LC), overall survival (OS). Cox proportional hazards regression models identified factors associated with LC and OS.

Results: The median follow-up for living patients was 38.6 months. Patients had primary (n=17) or metastatic (n=63) tumors. The median tumor size was 2.7 cm (range, 0.6-14.0). The 1 and 4 year rates of LC were 89.4% and 88%, respectively. Colorectal (CRC) metastasis was associated with lower rates of LC (p=0.013). OS at 1 and 4 years was 78% and 25%, respectively. Patients with CRC metastases had higher rates of OS (p=0.03). The occurrence of severe acute and late toxicity was 3.8% and 6.3%, respectively.

Conclusions: SBRT should be studied in prospective clinical trials compared with other liver-directed treatment modalities.

Keywords: liver metastasis; liver tumor; local control; radiation therapy; radiation-induced liver disease; stereotactic body radiotherapy.

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Conflict of interest statement

Authors’ disclosure of potential conflicts of interest The authors reported no conflict of interest.

Figures

Figure 1
Figure 1
A. Local control for all patients. B. Tumor response based on RECIST criteria C. Local control for patients with colorectal cancer vs. all others. D. Local control for patients with tumor > or ≤ 3cm. CRC=colorectal cancer
Figure 2
Figure 2
A. Overall survival for all patients from the completion of SBRT. B. Overall survival comparing patients with colorectal cancer primary compared to all others. C. Progression free survival following SBRT for the entire group.
See this image and copyright information in PMC

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