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. 1989 Mar;160(3):563-6.
doi: 10.1016/s0002-9378(89)80027-4.

Mechanism and clinical significance of elevated CA 125 levels in the sera of pregnant women

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Mechanism and clinical significance of elevated CA 125 levels in the sera of pregnant women

F Kobayashi et al. Am J Obstet Gynecol. 1989 Mar.

Abstract

To clarify the mechanism of CA 125 elevation in maternal sera, serum levels of CA 125 and CA 19-9 were measured in 122 apparently healthy pregnant women (fifth to fortieth week of gestation) and 50 postpartum women (26 term deliveries and 24 second-trimester induced abortions). Serum levels of CA 125 showed an initial increase by the tenth week and then decreased to less than 35 U/ml, remaining below this level until delivery. However, within 1 hour after term delivery or second-trimester induced abortion, the CA 125 levels showed a second increase and decreased rapidly thereafter. In contrast, serum levels of CA 19-9 did not change significantly during these periods. Combined with our previous finding that the decidua contains abundant CA 125 but little CA 19-9, these results indicate that the elevated CA 125 levels in maternal sera originate from the decidual cells affected by chorionic invasion or the placental separation.

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Comment in

  • CA 125 levels analyzed.
    Fuith LC. Fuith LC. Am J Obstet Gynecol. 1990 May;162(5):1358-9. doi: 10.1016/0002-9378(90)90081-h. Am J Obstet Gynecol. 1990. PMID: 2339747 No abstract available.

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