Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Oct 30;1(24):2161-2165.
doi: 10.1182/bloodadvances.2017012351. eCollection 2017 Nov 14.

Management of thrombotic thrombocytopenic purpura without plasma exchange: the Jehovah's Witness experience

James N George  1   2 , Steven A Sandler  3 , Joanna Stankiewicz  3
Affiliations

Management of thrombotic thrombocytopenic purpura without plasma exchange: the Jehovah's Witness experience

James N George et al. Blood Adv. .

Abstract

TTP in Jehovah's Witness patients has been managed successfully without PEX.This experience, plus new TTP treatments, may make it possible for patients who are not Jehovah's Witnesses to avoid PEX in the future.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: For J.N.G., Ablynx, developer of caplacizumab, provided partial salary support for a research assistant in 2016 for organization of Oklahoma TTP Registry data that were published in a previous Blood Advances article. The remaining authors declare no competing financial interests.

References

    1. Rock GA, Shumak KH, Buskard NA, et al. ; Canadian Apheresis Study Group. Comparison of plasma exchange with plasma infusion in the treatment of thrombotic thrombocytopenic purpura. N Engl J Med. 1991;325(6):393-397. - PubMed
    1. Committee for Hospital Information for Jehovah’s Witnesses. Religious and Ethical Position on Medical Therapy and Related Matters. https://www.jw.org/en/medical-library/strategies-downloads/religious-and.... Accessed 8 October 2017.
    1. Peyvandi F, Mannucci PM, Valsecchi C, Pontiggia S, Farina C, Retzios AD. ADAMTS13 content in plasma-derived factor VIII/von Willebrand factor concentrates. Am J Hematol. 2013;88(10):895-898. - PubMed
    1. Naik S, Mahoney DH. Successful treatment of congenital TTP with a novel approach using plasma-derived factor VIII. J Pediatr Hematol Oncol. 2013;35(7):551-553. - PubMed
    1. Dabak V, Kuriakose P, Raman S. Successful management of a Jehovah’s Witness with thrombotic thrombocytopenic purpura unwilling to be treated with therapeutic plasma exchange. J Clin Apher. 2007;22(6):330-332. - PubMed

LinkOut - more resources