Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar 4;14(3):657-670.
doi: 10.1080/21645515.2017.1423153. Epub 2018 Jan 30.

Influenza vaccines: Evaluation of the safety profile

Claudia Maria Trombetta  1 , Elena Gianchecchi  2 , Emanuele Montomoli  1   2
Affiliations
Review

Influenza vaccines: Evaluation of the safety profile

Claudia Maria Trombetta et al. Hum Vaccin Immunother. .

Abstract

The safety of vaccines is a critical factor in maintaining public trust in national vaccination programs. Vaccines are recommended for children, adults and elderly subjects and have to meet higher safety standards, since they are administered to healthy subjects, mainly healthy children. Although vaccines are strictly monitored before authorization, the possibility of adverse events and/or rare adverse events cannot be totally eliminated. Two main types of influenza vaccines are currently available: parenteral inactivated influenza vaccines and intranasal live attenuated vaccines. Both display a good safety profile in adults and children. However, they can cause adverse events and/or rare adverse events, some of which are more prevalent in children, while others with a higher prevalence in adults. The aim of this review is to provide an overview of influenza vaccine safety according to target groups, vaccine types and production methods.

Keywords: adverse events; age-groups; influenza vaccines; safety; vaccine types.

PubMed Disclaimer

References

    1. Trombetta CM, Montomoli E. Influenza immunology evaluation and correlates of protection: a focus on vaccines. Expert Rev Vaccines. 2016;15(8):967–76. doi:10.1586/14760584.2016.1164046. - DOI - PubMed
    1. Grohskopf LA, Sokolow LZ, Olsen SJ, Bresee JS, Broder KR, Karron RA. Prevention and control of influenza with vaccines: recommendations of the advisory committee on immunization practices, United States, 2015–16. Influenza Season. Morb Mortal Wkly Rep (MMWR). 2005;64(30):818–825. CDC. - PMC - PubMed
    1. Global Advisory Committee on Vaccine, S. and W.H.O secretariat, Global safety of vaccines: strengthening systems for monitoring, management and the role of GACVS. Expert Rev Vaccines. 2009;8(6):705–16. doi:10.1586/erv.09.40. - DOI - PubMed
    1. Halsey NA. The science of evaluation of adverse events associated with vaccination. Semin Pediatr Infect Dis. 2002;13(3):205–14. doi:10.1053/spid.2002.125864. - DOI - PubMed
    1. WHO Casuality assessment of an adverse event following immunizaiton (AEFI). 2013;1–56. ISBN: 978 92 4 150533 8.

MeSH terms