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Comment
. 2018 Jan 2;26(1):1-2.
doi: 10.1016/j.str.2017.12.009.

Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase

Luca Pellegrini  1
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Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase

Luca Pellegrini. Structure. .
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Abstract

Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al. (2018) reveal that a hook-like structure formed by the unique Dcc1 and Ctf8 subunits mediates the interaction of Ctf18-RFC with the leading strand DNA polymerase ɛ.

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