Ezh2-dependent therapies in bladder cancer: synthetic lethality

Cristina Segovia^{1

2

3}, Jesús M Paramio^{1

2

3}

Affiliations

¹ Unidad de Oncología Molecular, CIEMAT (ed70A), Madrid, Spain.
² Grupo de Oncología celular y Molecular, Hospital Universitario 12 de Octubre, Madrid, Spain.
³ Centro de Investigación Biomédica en Red de Cáncer (CIBER ONC), Spain.

Editorial

Cristina Segovia et al. Ann Transl Med. 2017 Dec.

. 2017 Dec;5(24):494.

doi: 10.21037/atm.2017.10.08.

Cristina Segovia^{1

2

3}, Jesús M Paramio^{1

2

3}

¹ Unidad de Oncología Molecular, CIEMAT (ed70A), Madrid, Spain.
² Grupo de Oncología celular y Molecular, Hospital Universitario 12 de Octubre, Madrid, Spain.
³ Centro de Investigación Biomédica en Red de Cáncer (CIBER ONC), Spain.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.
Ler LD, Ghosh S, Chai X, Thike AA, Heng HL, Siew EY, Dey S, Koh LK, Lim JQ, Lim WK, Myint SS, Loh JL, Ong P, Sam XX, Huang D, Lim T, Tan PH, Nagarajan S, Cheng CW, Ho H, Ng LG, Yuen J, Lin PH, Chuang CK, Chang YH, Weng WH, Rozen SG, Tan P, Creasy CL, Pang ST, McCabe MT, Poon SL, Teh BT. Ler LD, et al. Sci Transl Med. 2017 Feb 22;9(378):eaai8312. doi: 10.1126/scitranslmed.aai8312. Sci Transl Med. 2017. PMID: 28228601

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