Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
- PMID: 29301565
- PMCID: PMC5755287
- DOI: 10.1186/s13073-017-0512-3
Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward
Abstract
Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.
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Competing interests
The authors declare that they have no competing interests.
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References
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- Charney DS, Buxbaum JD, Sklar P, Nestler EJ. Neurobiology of mental illness. 4. Oxford: Oxford University Press; 2013.
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