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. 2018 Jan 4;10(1):1.
doi: 10.1186/s13073-017-0512-3.

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward

Affiliations

Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward

Krishna C Vadodaria et al. Genome Med. .

Abstract

Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

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Conflict of interest statement

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
A summary of the strengths and weaknesses of common psychiatric research methods. The challenge of elucidating disease mechanisms in psychiatric disorders requires a diverse array of research tools. Each of these tools has unique strengths (red) and weaknesses (blue), thereby complementing one another. Here we summarize four techniques: induced pluripotent stem cell (iPSC) models, rodent models, genome-wide association studies (GWAS), and neuroimaging

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