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Review
. 2018 Feb;38(2):292-303.
doi: 10.1161/ATVBAHA.117.309524. Epub 2018 Jan 4.

Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council

Peggy Robinet  1 , Dianna M Milewicz  1 , Lisa A Cassis  1 , Nicholas J Leeper  1 , Hong S Lu  1 , Jonathan D Smith  2
Affiliations
Review

Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council

Peggy Robinet et al. Arterioscler Thromb Vasc Biol. 2018 Feb.

Abstract

There are many differences in arterial diseases between men and women, including prevalence, clinical manifestations, treatments, and prognosis. The new policy of the National Institutes of Health, which requires the inclusion of sex as a biological variable for preclinical studies, aims to foster new mechanistic insights and to enhance our understanding of sex differences in human diseases. The purpose of this statement is to suggest guidelines for designing and reporting sex as a biological variable in animal models of atherosclerosis, thoracic and abdominal aortic aneurysms, and peripheral arterial disease. We briefly review sex differences of these human diseases and their animal models, followed by suggestions on experimental design and reporting of animal studies for these vascular pathologies.

Keywords: animal models; aortic aneurysms; atherosclerosis; peripheral arterial disease.

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References

    1. Mozaffarian D, Benjamin EJ, Go AS, et al. Executive summary: Heart disease and stroke statistics--2016 update: A report from the American Heart Association. Circulation. 2016;133:447–454. - PubMed
    1. Kawamoto KR, Davis MB, Duvernoy CS. Acute coronary syndromes: Differences in men and women. Curr Atheroscler Rep. 2016;18:73. - PubMed
    1. Maric-Bilkan C, Arnold AP, Taylor DA, Dwinell M, Howlett SE, Wenger N, Reckelhoff JF, Sandberg K, Churchill G, Levin E, Lundberg MS. Report of the National Heart, Lung, and Blood Institute working group on sex differences research in cardiovascular disease: Scientific questions and challenges. Hypertension. 2016;67:802–807. - PMC - PubMed
    1. Miller LR, Marks C, Becker JB, et al. Considering sex as a biological variable in preclinical research. FASEB J. 2017;31:29–34. - PMC - PubMed
    1. Daugherty A, Hegele RA, Mackman N, Rader DJ, Schmidt AM, Weber C. Complying with the National Institutes of Health guidelines and principles for rigor and reproducibility: Refutations. Arterioscler Thromb Vasc Biol. 2016;36:1303–1304. - PubMed