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. 2017 Dec;22(4):241-247.
doi: 10.15430/JCP.2017.22.4.241. Epub 2017 Dec 30.

Secondary Primary Prostate Cancer after Colorectal Cancer: A Nationwide Population-based Cohort Study in Korea

Hyun Soo Kim  1 , Yoon Jin Choi  1 , Dong Woo Shin  1 , Kyung-Do Han  2 , Hyuk Yoon  1 , Cheol Min Shin  1 , Young Soo Park  1 , Nayoung Kim  1   3 , Dong Ho Lee  1   3
Affiliations

Secondary Primary Prostate Cancer after Colorectal Cancer: A Nationwide Population-based Cohort Study in Korea

Hyun Soo Kim et al. J Cancer Prev. 2017 Dec.

Abstract

Background: Colorectal cancer (CRC) and prostate cancer frequently occur in developed countries. There are several reports on the association between CRC and prostate cancer; however, the conclusions are inconsistent to investigate the association of the development of secondary primary prostate cancer among patients with prior primary CRC using a nationwide population-based dataset.

Methods: Patients registered in the Republic of Korea National Health Insurance System database who were diagnosed with CRC between 2007 and 2012 were followed-up until the end of 2015, and we investigated the new diagnosis secondary primary prostate cancer. We compared the incidence of prostate cancer in age-matched controls using the Cox proportional hazards models.

Results: We analyzed a total of 85,455 first primary CRC survivors. During the follow-up period of 494,222 person-years, 2,005 patients (2.30%) developed secondary primary prostate cancer (incidence rate 4.06/1,000 person-years). The median duration of follow-up was 5.78 years. Compared with the general population, CRC patients had a significantly increased risk of secondary primary prostate cancer (HR = 2.30, 95% CI = 2.18-2.43; P < 0.001). Multivariate analysis (including age, sex, body mass index, hypertension, diabetes mellitus, dyslipidemia, and income) showed that age < 55 years (HR = 20.74, 95% CI = 11.81-36.41; P < 0.001) is a significant independent predictor of secondary primary prostate cancer development.

Conclusions: Men diagnosed with colorectal cancer are at an increased risk of secondary primary prostate cancer, particularly those aged < 55 years. The data suggests that colorectal cancer patients aged < 55 years require regular screening for prostate cancer.

Keywords: Colorectal neoplasm; Prostatic neoplasm; Second primary neoplasms.

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Conflict of interest statement

CONFLICTS OF INTEREST No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1
CONSORT flow diagram of patient recruitment. CRC, colorectal cancer; NHIS, National Health Insurance System; SPPC, secondary primary prostate cancer.
Figure 2
Figure 2
Cumulative incidence of prostate cancer in colorectal cancer (CRC) patients and general population.
See this image and copyright information in PMC

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