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. 2018 Feb;135(2):299-301.
doi: 10.1007/s00401-018-1805-3. Epub 2018 Jan 4.

Circumscribed/non-diffuse histology confers a better prognosis in H3K27M-mutant gliomas

Drew Pratt  1 , Siva Kumar Natarajan  1 , Adam Banda  1 , Caterina Giannini  2 , Pankaj Vats  3 , Carl Koschmann  4 , Rajen Mody  4 , Arul Chinnaiyan  3 , Sriram Venneti  5
Affiliations

Circumscribed/non-diffuse histology confers a better prognosis in H3K27M-mutant gliomas

Drew Pratt et al. Acta Neuropathol. 2018 Feb.
No abstract available

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Conflict of interest statement

Conflict of interest: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Histopathology, localization, and survival analyses in H3K27M-mutant circumscribed gliomas. a–d. Representative histology of a ganglion cell tumor (a–b, H&E) with nuclear expression of the H3K27M mutant protein (c) and concurrent loss of H3K27me3 (d) e. Kaplan-Meier estimation shows stratification of overall survival based on growth pattern and H3K27M mutation status (circumscribed glioma H3-wildtype, n=63; circumscribed glioma H3K27M-mutant, n=21; diffuse glioma H3/IDH-wildtype, n=550; diffuse glioma H3K27M-mutant, n=432). f. H3K27M mutation demonstrated a worse prognosis compared to H3-wildtype tumors in grade I-matched circumscribed gliomas. g. Locations of H3K27M-mutant circumscribed gliomas. h. Cox regression analysis.
See this image and copyright information in PMC

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