Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2018 Mar 1;22(1):42-48.
doi: 10.5935/1518-0557.20180009.

Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium

Aixa Molina  1   2 , Jose Sánchez  1   2 , William Sánchez  1   2 , Vanessa Vielma  1   2
Affiliations
Clinical Trial

Platelet-rich plasma as an adjuvant in the endometrial preparation of patients with refractory endometrium

Aixa Molina et al. JBRA Assist Reprod. .

Abstract

Objective: To improve endometrial quality and implantation rates after the administration of platelet-rich plasma in patients with refractory endometrium.

Methods: 19 patients undergoing in vitro fertilization, aged between 33 and 45 years with a history of refractory endometrium, to whom platelet rich plasma was given by infusion with a catheter into the uterine cavity on the tenth day of the hormone replacement therapy, and then 72 hours after the first administration.

Results: Endometrial thicknesses >7mm was reported with the first use; and in all cases, endometrial thicknesses >9mm were evident after the second administration. The entire study group qualified for Embryo Transfer at the blastocyst stage. We had 73.7% of positive pregnancy tests, of which 26.3% yielded live births; 26.3% ongoing pregnancies; 10.5% biochemical pregnancies; 5.3% anembryonic pregnancies and 5.3% had fetal death (16 weeks).

Conclusions: Platelet-rich plasma and its biostimulation effects on the endometrial microvasculature seems to be beneficial to patients with refractory endometrium, providing an increase in endometrial receptivity and a consequent increase in implantation rates. As an autologous resource, they are easy to obtain and inexpensive. Thus, we recommend it to be included in the different protocols for endometrial preparation, including those in which a natural cycle is preferred.

Keywords: Platelet-rich plasma; endometrial thickness; refractory endometrium.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST

No conflict of interest has been declared.

References

    1. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004;91:4–15. doi: 10.1160/TH03-07-0440. - DOI - PubMed
    1. Barad DH, Yu Y, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, Gleicher N. A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial thickness and clinical pregnancy rates. Fertil Steril. 2014;101:710–715. doi: 10.1016/j.fertnstert.2013.12.016. - DOI - PubMed
    1. Chang Y, Li J, Chen Y, Wei L, Yang X, Shi Y, Liang X. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. Int J Clin Exp Med. 2015;8:1286–1290. - PMC - PubMed
    1. Coughlan C, Ledger W, Wang Q, Liu F, Demirol A, Gurgan T, Cutting R, Ong K, Sallam H, Li TC. Recurrent implantation failure: definition and management. Reprod Biomed Online. 2014;28:14–38. doi: 10.1016/j.rbmo.2013.08.011. - DOI - PubMed
    1. Del Priore G, Saso S, Meslin EM, Tzakis A, Brännström M, Clarke A, Vianna R, Sawyer R, Smith JR. Uterine transplantation--a real possibility? The Indianapolis consensus. Hum Reprod. 2013;28:288–291. - PubMed

Publication types

MeSH terms