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Comment
. 2018 Jan 4;22(1):14-15.
doi: 10.1016/j.stem.2017.12.005.

The Skin(ny) on Regenerating the Largest Organ to Save a Patient's Life

Rui Yi  1
Affiliations
Comment

The Skin(ny) on Regenerating the Largest Organ to Save a Patient's Life

Rui Yi. Cell Stem Cell. .

Abstract

Stem cells hold enormous potential to regenerate an entire organ for organ replacement therapy. Recently, in Nature, Hirsch et al. (2017) restored the expression of laminin-332 in epidermal stem cells isolated from an individual with junctional epidermolysis bullosa and grafted the entire skin back to save the patient's life.

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Comment on

  • Regeneration of the entire human epidermis using transgenic stem cells.
    Hirsch T, Rothoeft T, Teig N, Bauer JW, Pellegrini G, De Rosa L, Scaglione D, Reichelt J, Klausegger A, Kneisz D, Romano O, Secone Seconetti A, Contin R, Enzo E, Jurman I, Carulli S, Jacobsen F, Luecke T, Lehnhardt M, Fischer M, Kueckelhaus M, Quaglino D, Morgante M, Bicciato S, Bondanza S, De Luca M. Hirsch T, et al. Nature. 2017 Nov 16;551(7680):327-332. doi: 10.1038/nature24487. Epub 2017 Nov 8. Nature. 2017. PMID: 29144448 Free PMC article.

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