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Comment
. 2018 Jan 4;22(1):5-7.
doi: 10.1016/j.stem.2017.12.014.

Chewing through Roots: How Leukemia Invades and Disrupts the Bone Marrow Microenvironment

Owen J Tamplin  1
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Chewing through Roots: How Leukemia Invades and Disrupts the Bone Marrow Microenvironment

Owen J Tamplin. Cell Stem Cell. .
Free article

Abstract

The bone marrow (BM) niche is a complex microenvironment that supports healthy hematopoietic stem cells (HSCs) throughout life. In this issue of Cell Stem Cell, Duarte et al. (2018) reveal the spatio-temporal progress of leukemic cells as they invade and occupy the niche, ultimately outcompeting native HSCs.

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  • Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.
    Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C. Duarte D, et al. Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6. doi: 10.1016/j.stem.2017.11.006. Epub 2017 Dec 21. Cell Stem Cell. 2018. PMID: 29276143 Free PMC article.

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